Increased coronary perivascular adipose tissue volume in patients with vasospastic angina

Kazuma Ohyama, Yasuharu Matsumoto, Kensuke Nishimiya, Kiyotaka Hao, Ryuji Tsuburaya, Hideki Ota, Hirokazu Amamizu, Hironori Uzuka, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Background: Recent studies have suggested that coronary perivascular adipose tissue (PVAT) impairs coronary vasomotion, so we examined whether PVAT is increased at the spastic coronary segment in patients with vasospastic angina (VSA). Methods and Results: PVAT volume in the left anterior descending (LAD) coronary arteries on CT coronary angiography was significantly increased in 48 VSA patients with LAD spasm compared with 18 controls (30.7±2.0 vs. 21.0±3.2 cm3, P=0.01), whereas that of total epicardial adipose tissue was comparable between the 2 groups. Conclusions: The results suggested an important role of PVAT in the pathogenesis of coronary spasm.

Original languageEnglish
Pages (from-to)1653-1656
Number of pages4
JournalCirculation Journal
Issue number7
Publication statusPublished - 2016


  • Adipose tissue
  • Computed tomography
  • Coronary spasm


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