Increased coronary perivascular adipose tissue volume in patients with vasospastic angina

Kazuma Ohyama; Yasuharu Matsumoto; Kensuke Nishimiya; Kiyotaka Hao; Ryuji Tsuburaya; Hideki Ota; Hirokazu Amamizu; Hironori Uzuka; Jun Takahashi; Kenta Ito; Hiroaki Shimokawa

doi:10.1253/circj.CJ-16-0213

Increased coronary perivascular adipose tissue volume in patients with vasospastic angina

Kazuma Ohyama, Yasuharu Matsumoto, Kensuke Nishimiya, Kiyotaka Hao, Ryuji Tsuburaya, Hideki Ota, Hirokazu Amamizu, Hironori Uzuka, Jun Takahashi, Kenta Ito, Hiroaki Shimokawa

Tohoku University

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Background: Recent studies have suggested that coronary perivascular adipose tissue (PVAT) impairs coronary vasomotion, so we examined whether PVAT is increased at the spastic coronary segment in patients with vasospastic angina (VSA). Methods and Results: PVAT volume in the left anterior descending (LAD) coronary arteries on CT coronary angiography was significantly increased in 48 VSA patients with LAD spasm compared with 18 controls (30.7±2.0 vs. 21.0±3.2 cm3, P=0.01), whereas that of total epicardial adipose tissue was comparable between the 2 groups. Conclusions: The results suggested an important role of PVAT in the pathogenesis of coronary spasm.

Original language	English
Pages (from-to)	1653-1656
Number of pages	4
Journal	Circulation Journal
Volume	80
Issue number	7
DOIs	https://doi.org/10.1253/circj.CJ-16-0213
Publication status	Published - 2016

Keywords

Adipose tissue
Computed tomography
Coronary spasm

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10.1253/circj.CJ-16-0213

Cite this

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title = "Increased coronary perivascular adipose tissue volume in patients with vasospastic angina",

abstract = "Background: Recent studies have suggested that coronary perivascular adipose tissue (PVAT) impairs coronary vasomotion, so we examined whether PVAT is increased at the spastic coronary segment in patients with vasospastic angina (VSA). Methods and Results: PVAT volume in the left anterior descending (LAD) coronary arteries on CT coronary angiography was significantly increased in 48 VSA patients with LAD spasm compared with 18 controls (30.7±2.0 vs. 21.0±3.2 cm3, P=0.01), whereas that of total epicardial adipose tissue was comparable between the 2 groups. Conclusions: The results suggested an important role of PVAT in the pathogenesis of coronary spasm.",

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author = "Kazuma Ohyama and Yasuharu Matsumoto and Kensuke Nishimiya and Kiyotaka Hao and Ryuji Tsuburaya and Hideki Ota and Hirokazu Amamizu and Hironori Uzuka and Jun Takahashi and Kenta Ito and Hiroaki Shimokawa",

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doi = "10.1253/circj.CJ-16-0213",

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TY - JOUR

T1 - Increased coronary perivascular adipose tissue volume in patients with vasospastic angina

AU - Ohyama, Kazuma

AU - Matsumoto, Yasuharu

AU - Nishimiya, Kensuke

AU - Hao, Kiyotaka

AU - Tsuburaya, Ryuji

AU - Ota, Hideki

AU - Amamizu, Hirokazu

AU - Uzuka, Hironori

AU - Takahashi, Jun

AU - Ito, Kenta

AU - Shimokawa, Hiroaki

PY - 2016

Y1 - 2016

N2 - Background: Recent studies have suggested that coronary perivascular adipose tissue (PVAT) impairs coronary vasomotion, so we examined whether PVAT is increased at the spastic coronary segment in patients with vasospastic angina (VSA). Methods and Results: PVAT volume in the left anterior descending (LAD) coronary arteries on CT coronary angiography was significantly increased in 48 VSA patients with LAD spasm compared with 18 controls (30.7±2.0 vs. 21.0±3.2 cm3, P=0.01), whereas that of total epicardial adipose tissue was comparable between the 2 groups. Conclusions: The results suggested an important role of PVAT in the pathogenesis of coronary spasm.

AB - Background: Recent studies have suggested that coronary perivascular adipose tissue (PVAT) impairs coronary vasomotion, so we examined whether PVAT is increased at the spastic coronary segment in patients with vasospastic angina (VSA). Methods and Results: PVAT volume in the left anterior descending (LAD) coronary arteries on CT coronary angiography was significantly increased in 48 VSA patients with LAD spasm compared with 18 controls (30.7±2.0 vs. 21.0±3.2 cm3, P=0.01), whereas that of total epicardial adipose tissue was comparable between the 2 groups. Conclusions: The results suggested an important role of PVAT in the pathogenesis of coronary spasm.

KW - Adipose tissue

KW - Computed tomography

KW - Coronary spasm

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SP - 1653

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JO - Circulation Journal

JF - Circulation Journal

IS - 7

ER -

Increased coronary perivascular adipose tissue volume in patients with vasospastic angina

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Keywords

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