Increased interleukin-19 expression in cutaneous T-cell lymphoma and atopic dermatitis

Tomonori Oka; Makoto Sugaya; Naomi Takahashi; Rina Nakajima; Sayaka Otobe; Miyoko Kabasawa; Hiraku Suga; Tomomitsu Miyagaki; Yoshihide Asano; Shinichi Sato

doi:10.2340/00015555-2723

Increased interleukin-19 expression in cutaneous T-cell lymphoma and atopic dermatitis

Tomonori Oka, Makoto Sugaya, Naomi Takahashi, Rina Nakajima, Sayaka Otobe, Miyoko Kabasawa, Hiraku Suga, Tomomitsu Miyagaki, Yoshihide Asano, Shinichi Sato

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Interleukin-19 (IL-19), a pro-inflammatory cytokine known to stimulate the production of T helper type 2 (Th2) cytokines, is induced by IL-17A and highly expressed in the lesional skin of psoriasis and atopic dermatitis (AD). This aim of this study was to investigate whether IL-19 is involved in cutaneous T-cell lymphoma (CTCL) and AD. IL-19 levels were significantly higher in the sera of patients with AD and those with advanced-stage CTCL than in normal controls, correlating significantly with clinical disease markers. IL- 19 mRNA levels in lesional skin of both diseases were significantly elevated. Immunohistochemical staining revealed that IL-19 was expressed in the epidermis of AD skin and CTCL skin. In vitro, IL-17A and IL-4 increased IL-19 mRNA expression in human keratinocytes. Thus, IL-19 was increased in the sera and skin of AD and CTCL. These results suggest that IL-19 is important for bridging Th17 to Th2 in these diseases.

Original language	English
Pages (from-to)	1172-1177
Number of pages	6
Journal	Acta Dermato-Venereologica
Volume	97
Issue number	10
DOIs	https://doi.org/10.2340/00015555-2723
Publication status	Published - 2017 Nov
Externally published	Yes

Keywords

Atopic dermatitis
Cutaneous T-cell lymphoma
IL-17A
IL-19
IL-4
Keratinocytes

ASJC Scopus subject areas

Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2340/00015555-2723

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title = "Increased interleukin-19 expression in cutaneous T-cell lymphoma and atopic dermatitis",

abstract = "Interleukin-19 (IL-19), a pro-inflammatory cytokine known to stimulate the production of T helper type 2 (Th2) cytokines, is induced by IL-17A and highly expressed in the lesional skin of psoriasis and atopic dermatitis (AD). This aim of this study was to investigate whether IL-19 is involved in cutaneous T-cell lymphoma (CTCL) and AD. IL-19 levels were significantly higher in the sera of patients with AD and those with advanced-stage CTCL than in normal controls, correlating significantly with clinical disease markers. IL- 19 mRNA levels in lesional skin of both diseases were significantly elevated. Immunohistochemical staining revealed that IL-19 was expressed in the epidermis of AD skin and CTCL skin. In vitro, IL-17A and IL-4 increased IL-19 mRNA expression in human keratinocytes. Thus, IL-19 was increased in the sera and skin of AD and CTCL. These results suggest that IL-19 is important for bridging Th17 to Th2 in these diseases.",

keywords = "Atopic dermatitis, Cutaneous T-cell lymphoma, IL-17A, IL-19, IL-4, Keratinocytes",

author = "Tomonori Oka and Makoto Sugaya and Naomi Takahashi and Rina Nakajima and Sayaka Otobe and Miyoko Kabasawa and Hiraku Suga and Tomomitsu Miyagaki and Yoshihide Asano and Shinichi Sato",

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AU - Oka, Tomonori

AU - Sugaya, Makoto

AU - Takahashi, Naomi

AU - Nakajima, Rina

AU - Otobe, Sayaka

AU - Kabasawa, Miyoko

AU - Suga, Hiraku

AU - Miyagaki, Tomomitsu

AU - Asano, Yoshihide

AU - Sato, Shinichi

PY - 2017/11

Y1 - 2017/11

N2 - Interleukin-19 (IL-19), a pro-inflammatory cytokine known to stimulate the production of T helper type 2 (Th2) cytokines, is induced by IL-17A and highly expressed in the lesional skin of psoriasis and atopic dermatitis (AD). This aim of this study was to investigate whether IL-19 is involved in cutaneous T-cell lymphoma (CTCL) and AD. IL-19 levels were significantly higher in the sera of patients with AD and those with advanced-stage CTCL than in normal controls, correlating significantly with clinical disease markers. IL- 19 mRNA levels in lesional skin of both diseases were significantly elevated. Immunohistochemical staining revealed that IL-19 was expressed in the epidermis of AD skin and CTCL skin. In vitro, IL-17A and IL-4 increased IL-19 mRNA expression in human keratinocytes. Thus, IL-19 was increased in the sera and skin of AD and CTCL. These results suggest that IL-19 is important for bridging Th17 to Th2 in these diseases.

AB - Interleukin-19 (IL-19), a pro-inflammatory cytokine known to stimulate the production of T helper type 2 (Th2) cytokines, is induced by IL-17A and highly expressed in the lesional skin of psoriasis and atopic dermatitis (AD). This aim of this study was to investigate whether IL-19 is involved in cutaneous T-cell lymphoma (CTCL) and AD. IL-19 levels were significantly higher in the sera of patients with AD and those with advanced-stage CTCL than in normal controls, correlating significantly with clinical disease markers. IL- 19 mRNA levels in lesional skin of both diseases were significantly elevated. Immunohistochemical staining revealed that IL-19 was expressed in the epidermis of AD skin and CTCL skin. In vitro, IL-17A and IL-4 increased IL-19 mRNA expression in human keratinocytes. Thus, IL-19 was increased in the sera and skin of AD and CTCL. These results suggest that IL-19 is important for bridging Th17 to Th2 in these diseases.

KW - Atopic dermatitis

KW - Cutaneous T-cell lymphoma

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KW - IL-19

KW - IL-4

KW - Keratinocytes

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Increased interleukin-19 expression in cutaneous T-cell lymphoma and atopic dermatitis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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