TY - JOUR
T1 - Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages
AU - Honda, Shoko
AU - Saito, Mariko
AU - Dimaano, Efren M.
AU - Morales, Philip A.
AU - Alonzo, Maria T.G.
AU - Suarez, Lady Anne C.
AU - Koike, Natsuki
AU - Inoue, Shingo
AU - Kumatori, Atsushi
AU - Matias, Ronald R.
AU - Natividad, Filipinas F.
AU - Oishi, Kazunori
PY - 2009/5
Y1 - 2009/5
N2 - The relationship between the percent phagocytosis of platelets by differentiated THP-1 cells was examined using flowcytometry and the peripheral platelet counts as well as platelet-associated IgG (PAIgG) in 36 patients with secondary dengue virus (DV) infections. The percent phagocytosis and the levels of PAIgG were significantly increased in these patients during the acute phase compared with the healthy volunteers. The increased percent phagocytosis and PAIgG found during the acute phase significantly decreased during the convalescent phase. An inverse correlation between platelet count and the percent phagocytosis (P=0.011) and the levels of PAIgG (P=0.041) was found among these patients during the acute phase. No correlation was found, however, between the percent phagocytosis and the lev-els of PAIgG. Our present data suggest that accelerated platelet phagocytosis occurs during the acute phase of secondary DV infections, and it is one of the mechanisms of thrombocytopenia in this disease.
AB - The relationship between the percent phagocytosis of platelets by differentiated THP-1 cells was examined using flowcytometry and the peripheral platelet counts as well as platelet-associated IgG (PAIgG) in 36 patients with secondary dengue virus (DV) infections. The percent phagocytosis and the levels of PAIgG were significantly increased in these patients during the acute phase compared with the healthy volunteers. The increased percent phagocytosis and PAIgG found during the acute phase significantly decreased during the convalescent phase. An inverse correlation between platelet count and the percent phagocytosis (P=0.011) and the levels of PAIgG (P=0.041) was found among these patients during the acute phase. No correlation was found, however, between the percent phagocytosis and the lev-els of PAIgG. Our present data suggest that accelerated platelet phagocytosis occurs during the acute phase of secondary DV infections, and it is one of the mechanisms of thrombocytopenia in this disease.
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U2 - 10.4269/ajtmh.2009.80.841
DO - 10.4269/ajtmh.2009.80.841
M3 - Article
C2 - 19407135
AN - SCOPUS:66149131058
SN - 0002-9637
VL - 80
SP - 841
EP - 845
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -
