Increased plasma 8-isoprostane levels in hypertensive subjects: The Tsurugaya project

Atsushi Hozawa, Satoru Ebihara, Kaori Ohmori, Shinichi Kuriyama, Takashi Ugajin, Yayoi Koizumi, Yoshinori Suzuki, Toshifumi Matsui, Hiroyuki Arai, Yoshitaka Tsubono, Hidetada Sasaki, Ichiro Tsuji

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


To examine the relationship between 8-isoprostane and blood pressure, we measured plasma 8-isoprostane concentration and home blood pressure levels in an elderly Japanese population. Our study population comprised 569 subjects aged 70 years and over who were not receiving antihypertensive medication. On the basis of their blood pressure values, the participants were classified into three groups: normotensive (home blood pressure < 135/85 mmHg), hypertensive (home blood pressure 135/85-160/90 mmHg), and severely hypertensive (home blood pressure ≥160/90 mmHg). The mean plasma 8-isoprostane level in the severely hypertensive group (21.1±5.2 pg/ml) was significantly higher than that in the normotensive (20.2±4.9 pg/ml) or hypertensive (19.7±5.1 pg/ml) group, and this result was unchanged when we adjusted for possible confounding factors such as age, sex, use of vitamin A, C or E supplements, smoking status, drinking status, body mass index, use of non-steroidal anti-inflammatory drugs, history of diabetes, hypercholesterolemia, home heart rate and serum creatinine level. Thus, the level of plasma 8-isoprostane appears to be elevated in older subjects with severe hypertension.

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalHypertension Research
Issue number8
Publication statusPublished - 2004 Aug


  • Elderly
  • Home blood pressure measurement
  • Hypertension
  • Isoprostanes
  • Oxidative stress


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