Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters

Tomohiro Sawa; Mounia Mounawar; Masayuki Tatemichi; Isabelle Gilibert; Takahiko Katoh; Hiroshi Ohshima

doi:10.1016/j.canlet.2008.04.015

Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters

Tomohiro Sawa, Mounia Mounawar, Masayuki Tatemichi, Isabelle Gilibert, Takahiko Katoh, Hiroshi Ohshima

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Microsatellite polymorphism in the promoter region of the heme oxygenase-1 (HO-1) gene was analyzed jointly with that of the inducible nitric oxide synthase (iNOS) gene among Japanese subjects (control and gastric cancer patients). A higher promoter activity genotype of the HO-1 gene was associated with increased risk for gastric cancer in women. Gastric cancer risk was notably increased in subjects carrying a higher promoter activity genotype for both HO-1 and iNOS compared to those with a lower promoter activity genotype for both genes. Our data suggest that genetic polymorphisms of HO-1 and iNOS modulate individual susceptibility to gastric cancer risk.

Original language	English
Pages (from-to)	78-84
Number of pages	7
Journal	Cancer Letters
Volume	269
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2008.04.015
Publication status	Published - 2008 Sept 28

Keywords

Gastric cancer
Heme oxygenase-1
Inducible nitric oxide synthase
Inflammation
Polymorphism

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.canlet.2008.04.015

Cite this

Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters. / Sawa, Tomohiro; Mounawar, Mounia; Tatemichi, Masayuki et al.
In: Cancer Letters, Vol. 269, No. 1, 28.09.2008, p. 78-84.

Research output: Contribution to journal › Article › peer-review

@article{6fa593fabce84282bc1105c95c8c8f69,

title = "Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters",

abstract = "Microsatellite polymorphism in the promoter region of the heme oxygenase-1 (HO-1) gene was analyzed jointly with that of the inducible nitric oxide synthase (iNOS) gene among Japanese subjects (control and gastric cancer patients). A higher promoter activity genotype of the HO-1 gene was associated with increased risk for gastric cancer in women. Gastric cancer risk was notably increased in subjects carrying a higher promoter activity genotype for both HO-1 and iNOS compared to those with a lower promoter activity genotype for both genes. Our data suggest that genetic polymorphisms of HO-1 and iNOS modulate individual susceptibility to gastric cancer risk.",

keywords = "Gastric cancer, Heme oxygenase-1, Inducible nitric oxide synthase, Inflammation, Polymorphism",

author = "Tomohiro Sawa and Mounia Mounawar and Masayuki Tatemichi and Isabelle Gilibert and Takahiko Katoh and Hiroshi Ohshima",

year = "2008",

month = sep,

day = "28",

doi = "10.1016/j.canlet.2008.04.015",

language = "English",

volume = "269",

pages = "78--84",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters

AU - Sawa, Tomohiro

AU - Mounawar, Mounia

AU - Tatemichi, Masayuki

AU - Gilibert, Isabelle

AU - Katoh, Takahiko

AU - Ohshima, Hiroshi

PY - 2008/9/28

Y1 - 2008/9/28

N2 - Microsatellite polymorphism in the promoter region of the heme oxygenase-1 (HO-1) gene was analyzed jointly with that of the inducible nitric oxide synthase (iNOS) gene among Japanese subjects (control and gastric cancer patients). A higher promoter activity genotype of the HO-1 gene was associated with increased risk for gastric cancer in women. Gastric cancer risk was notably increased in subjects carrying a higher promoter activity genotype for both HO-1 and iNOS compared to those with a lower promoter activity genotype for both genes. Our data suggest that genetic polymorphisms of HO-1 and iNOS modulate individual susceptibility to gastric cancer risk.

AB - Microsatellite polymorphism in the promoter region of the heme oxygenase-1 (HO-1) gene was analyzed jointly with that of the inducible nitric oxide synthase (iNOS) gene among Japanese subjects (control and gastric cancer patients). A higher promoter activity genotype of the HO-1 gene was associated with increased risk for gastric cancer in women. Gastric cancer risk was notably increased in subjects carrying a higher promoter activity genotype for both HO-1 and iNOS compared to those with a lower promoter activity genotype for both genes. Our data suggest that genetic polymorphisms of HO-1 and iNOS modulate individual susceptibility to gastric cancer risk.

KW - Gastric cancer

KW - Heme oxygenase-1

KW - Inducible nitric oxide synthase

KW - Inflammation

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=49349098481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49349098481&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2008.04.015

DO - 10.1016/j.canlet.2008.04.015

M3 - Article

C2 - 18502573

AN - SCOPUS:49349098481

SN - 0304-3835

VL - 269

SP - 78

EP - 84

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this