Increased ventilatory response to acute hypoxia with high Hb-O2 affinity induced by Na-cyanate treatment in the rat.

Y. Fukuda; T. Kobayashi; H. Kimura; R. Maruyama

doi:10.1007/978-1-4615-9510-6_39

Increased ventilatory response to acute hypoxia with high Hb-O2 affinity induced by Na-cyanate treatment in the rat.

Y. Fukuda, T. Kobayashi, H. Kimura, R. Maruyama

Research output: Contribution to journal › Article › peer-review

Abstract

The effects on the ventilatory response to acute hypoxia of increasing the Hb-O2 affinity by NaOCN administration were studied in the halothane anesthetized spontaneously breathing rat. Increases in ventilation during the progressive hypoxia test were significantly augmented, and ventilatory depression occurring in severe hypoxia was clearly inhibited in the NaOCN-treated rat. Beneficial effects of NaOCN treatment probably result from the protection of respiratory regulating mechanism from functional deterioration in severe hypoxia.

Original language	English
Pages (from-to)	331-339
Number of pages	9
Journal	Advances in experimental medicine and biology
Volume	222
DOIs	https://doi.org/10.1007/978-1-4615-9510-6_39
Publication status	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-1-4615-9510-6_39

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abstract = "The effects on the ventilatory response to acute hypoxia of increasing the Hb-O2 affinity by NaOCN administration were studied in the halothane anesthetized spontaneously breathing rat. Increases in ventilation during the progressive hypoxia test were significantly augmented, and ventilatory depression occurring in severe hypoxia was clearly inhibited in the NaOCN-treated rat. Beneficial effects of NaOCN treatment probably result from the protection of respiratory regulating mechanism from functional deterioration in severe hypoxia.",

author = "Y. Fukuda and T. Kobayashi and H. Kimura and R. Maruyama",

year = "1988",

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AU - Maruyama, R.

PY - 1988

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AB - The effects on the ventilatory response to acute hypoxia of increasing the Hb-O2 affinity by NaOCN administration were studied in the halothane anesthetized spontaneously breathing rat. Increases in ventilation during the progressive hypoxia test were significantly augmented, and ventilatory depression occurring in severe hypoxia was clearly inhibited in the NaOCN-treated rat. Beneficial effects of NaOCN treatment probably result from the protection of respiratory regulating mechanism from functional deterioration in severe hypoxia.

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Increased ventilatory response to acute hypoxia with high Hb-O2 affinity induced by Na-cyanate treatment in the rat.

Abstract

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