Increases of neuropeptide Y-like immunoreactivity in plasma during insulin-induced hypoglycemia in man

Kazuhiro Takahashi; Toraichi Mouri; Osamu Murakami; Keiichi Itoi; Masahiko Sone; Makoto Ohneda; Mitsuru Nozuki; Kaoru Yoshinaga

doi:10.1016/0196-9781(88)90281-1

Increases of neuropeptide Y-like immunoreactivity in plasma during insulin-induced hypoglycemia in man

Kazuhiro Takahashi, Toraichi Mouri, Osamu Murakami, Keiichi Itoi, Masahiko Sone, Makoto Ohneda, Mitsuru Nozuki, Kaoru Yoshinaga

MED - Health Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Neuropeptide Y-like immunoreactivity (NPY-LI) in plasma during insulin-induced hypoglycemia was measured in 4 healthy male volunteers. Plasma NPY-LI increased from 167±11 pg/ml to 247±25 pg/ml 30 min after the administration of insulin (0.1 U/kg body weight IV), reached the maximum (296±6 pg/ml) 45 min after the insulin, and then decreased. These results suggest that NPY is released into the systemic circulation during insulin-induced hypoglycemia in man.

Original language	English
Pages (from-to)	433-435
Number of pages	3
Journal	Peptides
Volume	9
Issue number	2
DOIs	https://doi.org/10.1016/0196-9781(88)90281-1
Publication status	Published - 1988

Keywords

Insulin-induced hypoglycemia
Neuropeptide Y
Neuropeptide Y-like immunoreactivity
Radioimmunoassay

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10.1016/0196-9781(88)90281-1

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title = "Increases of neuropeptide Y-like immunoreactivity in plasma during insulin-induced hypoglycemia in man",

abstract = "Neuropeptide Y-like immunoreactivity (NPY-LI) in plasma during insulin-induced hypoglycemia was measured in 4 healthy male volunteers. Plasma NPY-LI increased from 167±11 pg/ml to 247±25 pg/ml 30 min after the administration of insulin (0.1 U/kg body weight IV), reached the maximum (296±6 pg/ml) 45 min after the insulin, and then decreased. These results suggest that NPY is released into the systemic circulation during insulin-induced hypoglycemia in man.",

keywords = "Insulin-induced hypoglycemia, Neuropeptide Y, Neuropeptide Y-like immunoreactivity, Radioimmunoassay",

author = "Kazuhiro Takahashi and Toraichi Mouri and Osamu Murakami and Keiichi Itoi and Masahiko Sone and Makoto Ohneda and Mitsuru Nozuki and Kaoru Yoshinaga",

note = "Funding Information: This studyh as beens upporteidn part by a Grant-in-Aidfo r ScientificR esearchfr om the Ministryo f EducationS, ciencea nd CultureJ,a pan( No. 615702958W).e thankM iss ToshieK atayanagi for her secretariaasl sistance.",

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doi = "10.1016/0196-9781(88)90281-1",

language = "English",

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pages = "433--435",

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T1 - Increases of neuropeptide Y-like immunoreactivity in plasma during insulin-induced hypoglycemia in man

AU - Takahashi, Kazuhiro

AU - Mouri, Toraichi

AU - Murakami, Osamu

AU - Itoi, Keiichi

AU - Sone, Masahiko

AU - Ohneda, Makoto

AU - Nozuki, Mitsuru

AU - Yoshinaga, Kaoru

N1 - Funding Information: This studyh as beens upporteidn part by a Grant-in-Aidfo r ScientificR esearchfr om the Ministryo f EducationS, ciencea nd CultureJ,a pan( No. 615702958W).e thankM iss ToshieK atayanagi for her secretariaasl sistance.

PY - 1988

Y1 - 1988

N2 - Neuropeptide Y-like immunoreactivity (NPY-LI) in plasma during insulin-induced hypoglycemia was measured in 4 healthy male volunteers. Plasma NPY-LI increased from 167±11 pg/ml to 247±25 pg/ml 30 min after the administration of insulin (0.1 U/kg body weight IV), reached the maximum (296±6 pg/ml) 45 min after the insulin, and then decreased. These results suggest that NPY is released into the systemic circulation during insulin-induced hypoglycemia in man.

AB - Neuropeptide Y-like immunoreactivity (NPY-LI) in plasma during insulin-induced hypoglycemia was measured in 4 healthy male volunteers. Plasma NPY-LI increased from 167±11 pg/ml to 247±25 pg/ml 30 min after the administration of insulin (0.1 U/kg body weight IV), reached the maximum (296±6 pg/ml) 45 min after the insulin, and then decreased. These results suggest that NPY is released into the systemic circulation during insulin-induced hypoglycemia in man.

KW - Insulin-induced hypoglycemia

KW - Neuropeptide Y

KW - Neuropeptide Y-like immunoreactivity

KW - Radioimmunoassay

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JO - Peptides

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Increases of neuropeptide Y-like immunoreactivity in plasma during insulin-induced hypoglycemia in man

Abstract

Keywords

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