TY - JOUR
T1 - Induction of antenatal periventricular leukomalacia by hemorrhagic hypotension in the chronically instrumented fetal sheep
AU - Matsuda, Tadashi
AU - Okuyama, Kazuhiko
AU - Cho, Kazutoshi
AU - Hoshi, Nobuhiko
AU - Matsumoto, Yoshinori
AU - Kobayashi, Yoshiyasu
AU - Fujimoto, Seiichiro
N1 - Funding Information:
Supported by a Grant-in-Aid for Scientific Research (No. 08457432) from the Ministry of Education, Science, Sports and Culture, Japan, and the Ogyaa Donation Foundation in Japan Association of Obstetricians and Gynecologists.
PY - 1999
Y1 - 1999
N2 - OBJECTIVES: Our purpose was to determine whether systemic hypotension induced by rapid withdrawal of fetal blood would induce periventricular leukomalacia in the brain of premature fetal sheep. STUDY DESIGN: At 113 days' gestation, systemic hypotension (mean blood pressure <30 mm Hg) was induced by withdrawing approximately 35% of the fetoplacental blood volume in the hemorrhage group (n = 6), whereas in the control group (n = 4) isovolemic exchange transfusion was carried out. Six days after the insult, fetal brains were removed and processed for histologic analysis. RESULTS: Five of the 6 fetuses in the hemorrhage group exhibited periventricular white-matter lesions, consisting of nodular coagulation necrosis or diffuse axonal swellings or both. No abnormal findings other than these lesions were detected in the fetal brains in either experimental group. CONCLUSION: Hemorrhagic hypotension antenatally induced brain lesions similar to those of periventricular leukomalacia, suggesting that it is an essential element in the pathogenesis of periventricular leukomalacia in premature fetuses.
AB - OBJECTIVES: Our purpose was to determine whether systemic hypotension induced by rapid withdrawal of fetal blood would induce periventricular leukomalacia in the brain of premature fetal sheep. STUDY DESIGN: At 113 days' gestation, systemic hypotension (mean blood pressure <30 mm Hg) was induced by withdrawing approximately 35% of the fetoplacental blood volume in the hemorrhage group (n = 6), whereas in the control group (n = 4) isovolemic exchange transfusion was carried out. Six days after the insult, fetal brains were removed and processed for histologic analysis. RESULTS: Five of the 6 fetuses in the hemorrhage group exhibited periventricular white-matter lesions, consisting of nodular coagulation necrosis or diffuse axonal swellings or both. No abnormal findings other than these lesions were detected in the fetal brains in either experimental group. CONCLUSION: Hemorrhagic hypotension antenatally induced brain lesions similar to those of periventricular leukomalacia, suggesting that it is an essential element in the pathogenesis of periventricular leukomalacia in premature fetuses.
KW - Brain damage
KW - Fetal sheep
KW - Hemorrhagic hypotension
KW - Prematurity
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U2 - 10.1016/S0002-9378(99)70519-3
DO - 10.1016/S0002-9378(99)70519-3
M3 - Article
C2 - 10486490
AN - SCOPUS:0032846102
SN - 0002-9378
VL - 181
SP - 725
EP - 730
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 3
ER -