Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus

Jun ichi Kawagoe; Koji Abe; Masashi Aoki; Kyuya Kogure

doi:10.1016/0006-8993(93)90306-8

Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus

Jun ichi Kawagoe, Koji Abe, Masashi Aoki, Kyuya Kogure

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Distribution of heat shock protein (HSP) 90α mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90α mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90α mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90α mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90α with other HSPs after ischemia.

Original language	English
Pages (from-to)	121-125
Number of pages	5
Journal	Brain Research
Volume	621
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)90306-8
Publication status	Published - 1993 Sept 3

Keywords

Cerebral ischemia
Gerbil
Heat shock protein 90
In situ hybridization

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10.1016/0006-8993(93)90306-8

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title = "Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus",

abstract = "Distribution of heat shock protein (HSP) 90α mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90α mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90α mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90α mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90α with other HSPs after ischemia.",

keywords = "Cerebral ischemia, Gerbil, Heat shock protein 90, In situ hybridization",

author = "Kawagoe, {Jun ichi} and Koji Abe and Masashi Aoki and Kyuya Kogure",

note = "Funding Information: This work was partly supported by a Monbusho Grant 01044018 and 03404028, a grant from the Ministry of Welfare and Health of Japan, and the Kowa Life Science Foundation. The authors would like to express their appreciation to Mrs. M. Matsumoto and Miss N. Igarashi for their excellent technical assistance.",

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T1 - Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus

AU - Kawagoe, Jun ichi

AU - Abe, Koji

AU - Aoki, Masashi

AU - Kogure, Kyuya

N1 - Funding Information: This work was partly supported by a Monbusho Grant 01044018 and 03404028, a grant from the Ministry of Welfare and Health of Japan, and the Kowa Life Science Foundation. The authors would like to express their appreciation to Mrs. M. Matsumoto and Miss N. Igarashi for their excellent technical assistance.

PY - 1993/9/3

Y1 - 1993/9/3

N2 - Distribution of heat shock protein (HSP) 90α mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90α mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90α mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90α mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90α with other HSPs after ischemia.

AB - Distribution of heat shock protein (HSP) 90α mRNA induction after 10 min of transient global ischemia was investigated in gerbil hippocampus by in situ hybridization. A small amount of HSP90α mRNA was normally present in hippocampal cells and the mRNA was further induced with a peak at 8 h after ischemia. In hippocampal CA1 cells that are vulnerable to ischemia, HSP90α mRNA was continuously induced by 1 day and finally diminished at 2 days. The temporal profile of HSP90α mRNA induction in hippocampal CA1 cells was similar to that of HSP70 mRNA reported previously, suggesting a cooperative role of HSP90α with other HSPs after ischemia.

KW - Cerebral ischemia

KW - Gerbil

KW - Heat shock protein 90

KW - In situ hybridization

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Induction of HSP90α heat shock mRNA after transient global ischemia in gerbil hippocampus

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