Induction of podoplanin by transforming growth factor-β in human fibrosarcoma

Hiroyuki Suzuki, Yukinari Kato, Mika Kato Kaneko, Yukari Okita, Hisashi Narimatsu, Mitsuyasu Kato

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-β (TGF-β) regulates many physiological events, including tumorigenesis. Here, we found that TGF-β induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-β type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-β. These results suggest that TGF-β is a physiological regulator of podoplanin in tumor cells.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalFEBS Letters
Issue number2
Publication statusPublished - 2008 Jan 23


  • Fibrosarcoma
  • Platelet aggregation
  • Podoplanin
  • Smad
  • TGF-β


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