Induction of podoplanin by transforming growth factor-β in human fibrosarcoma

Hiroyuki Suzuki; Yukinari Kato; Mika Kato Kaneko; Yukari Okita; Hisashi Narimatsu; Mitsuyasu Kato

doi:10.1016/j.febslet.2007.12.028

Induction of podoplanin by transforming growth factor-β in human fibrosarcoma

Hiroyuki Suzuki, Yukinari Kato, Mika Kato Kaneko, Yukari Okita, Hisashi Narimatsu, Mitsuyasu Kato

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-β (TGF-β) regulates many physiological events, including tumorigenesis. Here, we found that TGF-β induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-β type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-β. These results suggest that TGF-β is a physiological regulator of podoplanin in tumor cells.

Original language	English
Pages (from-to)	341-345
Number of pages	5
Journal	FEBS Letters
Volume	582
Issue number	2
DOIs	https://doi.org/10.1016/j.febslet.2007.12.028
Publication status	Published - 2008 Jan 23

Keywords

Fibrosarcoma
Platelet aggregation
Podoplanin
Smad
TGF-β

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2007.12.028

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title = "Induction of podoplanin by transforming growth factor-β in human fibrosarcoma",

abstract = "Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-β (TGF-β) regulates many physiological events, including tumorigenesis. Here, we found that TGF-β induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-β type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-β. These results suggest that TGF-β is a physiological regulator of podoplanin in tumor cells.",

keywords = "Fibrosarcoma, Platelet aggregation, Podoplanin, Smad, TGF-β",

author = "Hiroyuki Suzuki and Yukinari Kato and Kaneko, {Mika Kato} and Yukari Okita and Hisashi Narimatsu and Mitsuyasu Kato",

note = "Funding Information: We thank Ms. Nana Matsuura for technical assistance. This study was supported in part by grants-in-aid for Scientific Research from the Ministry of Education, Culture, Science, Sports and Technology of Japan (H. Suzuki), by Mitsubishi Pharma Research Foundation (Y. Kato), by the YASUDA Medical Foundation (Y. Kato), Inoue Foundation for Science (Y. Kato), and by the Osaka Cancer Research Foundation (MK. Kaneko).",

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AU - Suzuki, Hiroyuki

AU - Kato, Yukinari

AU - Kaneko, Mika Kato

AU - Okita, Yukari

AU - Narimatsu, Hisashi

AU - Kato, Mitsuyasu

N1 - Funding Information: We thank Ms. Nana Matsuura for technical assistance. This study was supported in part by grants-in-aid for Scientific Research from the Ministry of Education, Culture, Science, Sports and Technology of Japan (H. Suzuki), by Mitsubishi Pharma Research Foundation (Y. Kato), by the YASUDA Medical Foundation (Y. Kato), Inoue Foundation for Science (Y. Kato), and by the Osaka Cancer Research Foundation (MK. Kaneko).

PY - 2008/1/23

Y1 - 2008/1/23

N2 - Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-β (TGF-β) regulates many physiological events, including tumorigenesis. Here, we found that TGF-β induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-β type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-β. These results suggest that TGF-β is a physiological regulator of podoplanin in tumor cells.

AB - Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-β (TGF-β) regulates many physiological events, including tumorigenesis. Here, we found that TGF-β induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-β type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-β. These results suggest that TGF-β is a physiological regulator of podoplanin in tumor cells.

KW - Fibrosarcoma

KW - Platelet aggregation

KW - Podoplanin

KW - Smad

KW - TGF-β

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Induction of podoplanin by transforming growth factor-β in human fibrosarcoma

Abstract

Keywords

UN SDGs

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