TY - JOUR
T1 - Infiltration of CD40-positive tumor-associated macrophages indicates a favorable prognosis in colorectal cancer patients
AU - Kinouchi, Makoto
AU - Miura, Koh
AU - Mizoi, Takayuki
AU - Ishida, Kazuyuki
AU - Fujibuchi, Wataru
AU - Sasaki, Hiroyuki
AU - Ohnuma, Shinobu
AU - Saito, Kazuya
AU - Katayose, Yu
AU - Naitoh, Takeshi
AU - Motoi, Fuyuhiko
AU - Shiiba, Ken Ichi
AU - Egawa, Shinichi
AU - Shibata, Chikashi
AU - Unno, Michiaki
PY - 2013/3
Y1 - 2013/3
N2 - Background/Aims: Recently the role of tumor-associated macrophages (TAMs) on immunity has been variously discussed. We studied a series of cell surface antigens in TAMs in colorectal cancer tissues and their corresponding normal tissues using flow cytometry to find out prognostic indicators of these patients. Methodology: We assessed the numbers of CD14+ macrophages positive for each of the cell surface antigens (CD80, CD86, HLA-DR, CD1a, CD40 and CD83) in cancer tissues and corresponding normal tissues among 31 patients with colorectal cancer, and performed the univariate and multivariate analysis to find out prognostic indicators for overall survival among the patients. Results: The numbers of CD80+, CD86+ and HLA-DR+ TAMs in the cancer tissues were higher than those in corresponding normal tissues. Inversely CD40+ and CD83+ macrophages in cancer tissues were less than those in normal tissues. With the multivariate analysis, the number of CD40+ TAMs, as well as lymph node metastasis and distant metastasis, was shown to be an independent prognostic factor of colorectal cancer patients. Conclusions: The dense infiltration of CD40+ TAM in colorectal cancer tissues indicates a favorable prognosis, which suggests that CD40 plays an important role in the tumor immunity of colorectal cancer.
AB - Background/Aims: Recently the role of tumor-associated macrophages (TAMs) on immunity has been variously discussed. We studied a series of cell surface antigens in TAMs in colorectal cancer tissues and their corresponding normal tissues using flow cytometry to find out prognostic indicators of these patients. Methodology: We assessed the numbers of CD14+ macrophages positive for each of the cell surface antigens (CD80, CD86, HLA-DR, CD1a, CD40 and CD83) in cancer tissues and corresponding normal tissues among 31 patients with colorectal cancer, and performed the univariate and multivariate analysis to find out prognostic indicators for overall survival among the patients. Results: The numbers of CD80+, CD86+ and HLA-DR+ TAMs in the cancer tissues were higher than those in corresponding normal tissues. Inversely CD40+ and CD83+ macrophages in cancer tissues were less than those in normal tissues. With the multivariate analysis, the number of CD40+ TAMs, as well as lymph node metastasis and distant metastasis, was shown to be an independent prognostic factor of colorectal cancer patients. Conclusions: The dense infiltration of CD40+ TAM in colorectal cancer tissues indicates a favorable prognosis, which suggests that CD40 plays an important role in the tumor immunity of colorectal cancer.
KW - CD40
KW - Colon cancer
KW - Prognostic indicator
KW - Tumor-associated macrophage
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U2 - 10.5754/hge12372
DO - 10.5754/hge12372
M3 - Article
C2 - 22687258
AN - SCOPUS:84877698867
SN - 0172-6390
VL - 60
SP - 83
EP - 88
JO - Hepato-Gastroenterology
JF - Hepato-Gastroenterology
IS - 122
ER -
