Infrequent genetic alterations of the PTEN* gene in Japanese patients with sporadic prostate cancer

Kazuhiko Orikasa; Shin Ichi Fukushige; Senji Hoshi; Seiichi Orikasa; Keiichi Kondo; Yasuhide Miyoshi; Yoshinobu Kubota; Akira Horii

doi:10.1007/s100380050078

Infrequent genetic alterations of the PTEN* gene in Japanese patients with sporadic prostate cancer

Kazuhiko Orikasa, Shin Ichi Fukushige, Senji Hoshi, Seiichi Orikasa, Keiichi Kondo, Yasuhide Miyoshi, Yoshinobu Kubota, Akira Horii

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Prostate cancer is a major cause of cancer death among elderly men in America, Europe, and Japan. However, the molecular mechanism of carcinogenesis is not yet well characterized. Frequent loss of heterozygosity (LOH) on chromosome 10q was reported in prostate cancer, and a candidate tumor suppressor gene, PTEN, was isolated on chromosome band 10q23.3. To investigate the genetic alterations of PTEN, we examined 45 primary prostate cancer specimens. LOH at the PTEN locus was observed in two (11.1%) of 18 tumors. However, no mutations were observed in any of the primary prostate cancers. These data suggest that mutation of the PTEN gene does not play a major role in prostate carcinogenesis of Japanese patients.

Original language	English
Pages (from-to)	228-230
Number of pages	3
Journal	Journal of Human Genetics
Volume	43
Issue number	4
DOIs	https://doi.org/10.1007/s100380050078
Publication status	Published - 1998

Keywords

Chromosome 10q
Loss of heterozygosity (LOH)
Prostate cancer
PTEN gene
Tumor suppressor gene

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s100380050078

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title = "Infrequent genetic alterations of the PTEN* gene in Japanese patients with sporadic prostate cancer",

abstract = "Prostate cancer is a major cause of cancer death among elderly men in America, Europe, and Japan. However, the molecular mechanism of carcinogenesis is not yet well characterized. Frequent loss of heterozygosity (LOH) on chromosome 10q was reported in prostate cancer, and a candidate tumor suppressor gene, PTEN, was isolated on chromosome band 10q23.3. To investigate the genetic alterations of PTEN, we examined 45 primary prostate cancer specimens. LOH at the PTEN locus was observed in two (11.1%) of 18 tumors. However, no mutations were observed in any of the primary prostate cancers. These data suggest that mutation of the PTEN gene does not play a major role in prostate carcinogenesis of Japanese patients.",

keywords = "Chromosome 10q, Loss of heterozygosity (LOH), Prostate cancer, PTEN gene, Tumor suppressor gene",

author = "Kazuhiko Orikasa and Fukushige, {Shin Ichi} and Senji Hoshi and Seiichi Orikasa and Keiichi Kondo and Yasuhide Miyoshi and Yoshinobu Kubota and Akira Horii",

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T1 - Infrequent genetic alterations of the PTEN* gene in Japanese patients with sporadic prostate cancer

AU - Orikasa, Kazuhiko

AU - Fukushige, Shin Ichi

AU - Hoshi, Senji

AU - Orikasa, Seiichi

AU - Kondo, Keiichi

AU - Miyoshi, Yasuhide

AU - Kubota, Yoshinobu

AU - Horii, Akira

PY - 1998

Y1 - 1998

N2 - Prostate cancer is a major cause of cancer death among elderly men in America, Europe, and Japan. However, the molecular mechanism of carcinogenesis is not yet well characterized. Frequent loss of heterozygosity (LOH) on chromosome 10q was reported in prostate cancer, and a candidate tumor suppressor gene, PTEN, was isolated on chromosome band 10q23.3. To investigate the genetic alterations of PTEN, we examined 45 primary prostate cancer specimens. LOH at the PTEN locus was observed in two (11.1%) of 18 tumors. However, no mutations were observed in any of the primary prostate cancers. These data suggest that mutation of the PTEN gene does not play a major role in prostate carcinogenesis of Japanese patients.

AB - Prostate cancer is a major cause of cancer death among elderly men in America, Europe, and Japan. However, the molecular mechanism of carcinogenesis is not yet well characterized. Frequent loss of heterozygosity (LOH) on chromosome 10q was reported in prostate cancer, and a candidate tumor suppressor gene, PTEN, was isolated on chromosome band 10q23.3. To investigate the genetic alterations of PTEN, we examined 45 primary prostate cancer specimens. LOH at the PTEN locus was observed in two (11.1%) of 18 tumors. However, no mutations were observed in any of the primary prostate cancers. These data suggest that mutation of the PTEN gene does not play a major role in prostate carcinogenesis of Japanese patients.

KW - Chromosome 10q

KW - Loss of heterozygosity (LOH)

KW - Prostate cancer

KW - PTEN gene

KW - Tumor suppressor gene

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Infrequent genetic alterations of the PTEN* gene in Japanese patients with sporadic prostate cancer

Abstract

Keywords

UN SDGs

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