Abstract
Stomatitis caused by a combined chemotherapy with 5-fluorouracil (5-FU) and cisplatin (CDDP) is a serious problem in the course of treatment for patients with oral carcinoma. In the present study, we proposed a form of cryotherapy using an ice - bar containing fibrinolysin and deoxyribonuclease (Elase ®) to inhibit the stomatitis. The therapeutic effect of the ice-bar cryotherapy was evaluated in 20 patients with oral squamous cell carcinoma who were undergoing 5-FU-CDDP chemotherapy. Nine of the 20 patients were given the ice-bar cryotherapy while the remaining patients were not. As a result, although there was no significant difference between the incidence of stomatitis in the groups with and without the ice-bar cryotherapy, the incidence of severe stomatitis with ulcers and/or eating disturbance in the 11 cases without the ice-bar cryotherapy (90 %) was significantly higher than that in the 9 cases with the cryotherapy (44 %) (p<0.05). However, no significant difference in the clinical response rate of the 5-FU-CDDP chemotherapy was observed between the two groups.
Original language | English |
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Pages (from-to) | 1135-1139 |
Number of pages | 5 |
Journal | Japanese Journal of Cancer and Chemotherapy |
Volume | 24 |
Issue number | 9 |
Publication status | Published - 1997 |
Keywords
- Cancer chemotherapy
- Elase®-cryotherapy
- Stomatitis
ASJC Scopus subject areas
- Medicine(all)