Inhibition of bone resorption in cultures of mouse calvariae by apicularen A

Jang Ja Hong; Hirokazu Sasaki; Kazuaki Niikura; Maiko Yanai; Yasuhiro Nakano; Aya Yokomakura; Kenji Ishihara; Noriyasu Hirasawa; Young Sook Kang; Sub Oh Joa; Hwan Kwak Jong; Ok Pyo Zee; Kazuo Ohuchi

doi:10.1055/s-2006-957069

Inhibition of bone resorption in cultures of mouse calvariae by apicularen A

Jang Ja Hong, Hirokazu Sasaki, Kazuaki Niikura, Maiko Yanai, Yasuhiro Nakano, Aya Yokomakura, Kenji Ishihara, Noriyasu Hirasawa, Young Sook Kang, Sub Oh Joa, Hwan Kwak Jong, Ok Pyo Zee, Kazuo Ohuchi

PHA - Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Apicularens A and B were isolated from the myxobacterial genus Chondromyces apiculatus JW184. Apicularen A inhibited bafilomycin A1-sensitive ATP-dependent proton transport into microsome vesicles more potently than apicularen B. Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1β (IL-1β) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. The bisphosphonate incadronate inhibited bone resorption at 100 nM, being less effective than apicularen A. Our findings indicate that apicularen A inhibits bone resorption induced by PTH or IL-1β more potently than apicularen B, probably due to inhibition of the V-ATPase.

Original language	English
Pages (from-to)	173-175
Number of pages	3
Journal	Planta Medica
Volume	73
Issue number	2
DOIs	https://doi.org/10.1055/s-2006-957069
Publication status	Published - 2007 Feb

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title = "Inhibition of bone resorption in cultures of mouse calvariae by apicularen A",

abstract = "Apicularens A and B were isolated from the myxobacterial genus Chondromyces apiculatus JW184. Apicularen A inhibited bafilomycin A1-sensitive ATP-dependent proton transport into microsome vesicles more potently than apicularen B. Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1β (IL-1β) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. The bisphosphonate incadronate inhibited bone resorption at 100 nM, being less effective than apicularen A. Our findings indicate that apicularen A inhibits bone resorption induced by PTH or IL-1β more potently than apicularen B, probably due to inhibition of the V-ATPase.",

author = "Hong, {Jang Ja} and Hirokazu Sasaki and Kazuaki Niikura and Maiko Yanai and Yasuhiro Nakano and Aya Yokomakura and Kenji Ishihara and Noriyasu Hirasawa and Kang, {Young Sook} and Joa, {Sub Oh} and Jong, {Hwan Kwak} and Zee, {Ok Pyo} and Kazuo Ohuchi",

year = "2007",

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doi = "10.1055/s-2006-957069",

language = "English",

volume = "73",

pages = "173--175",

journal = "Planta Medica",

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T1 - Inhibition of bone resorption in cultures of mouse calvariae by apicularen A

AU - Hong, Jang Ja

AU - Sasaki, Hirokazu

AU - Niikura, Kazuaki

AU - Yanai, Maiko

AU - Nakano, Yasuhiro

AU - Yokomakura, Aya

AU - Ishihara, Kenji

AU - Hirasawa, Noriyasu

AU - Kang, Young Sook

AU - Joa, Sub Oh

AU - Jong, Hwan Kwak

AU - Zee, Ok Pyo

AU - Ohuchi, Kazuo

PY - 2007/2

Y1 - 2007/2

N2 - Apicularens A and B were isolated from the myxobacterial genus Chondromyces apiculatus JW184. Apicularen A inhibited bafilomycin A1-sensitive ATP-dependent proton transport into microsome vesicles more potently than apicularen B. Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1β (IL-1β) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. The bisphosphonate incadronate inhibited bone resorption at 100 nM, being less effective than apicularen A. Our findings indicate that apicularen A inhibits bone resorption induced by PTH or IL-1β more potently than apicularen B, probably due to inhibition of the V-ATPase.

AB - Apicularens A and B were isolated from the myxobacterial genus Chondromyces apiculatus JW184. Apicularen A inhibited bafilomycin A1-sensitive ATP-dependent proton transport into microsome vesicles more potently than apicularen B. Bone resorption in cultures of mouse calvariae induced by human parathyroid hormone (PTH) or interleukin-1β (IL-1β) was inhibited by apicularen A at 10 and 100 nM, while apicularen B had no effect. The bisphosphonate incadronate inhibited bone resorption at 100 nM, being less effective than apicularen A. Our findings indicate that apicularen A inhibits bone resorption induced by PTH or IL-1β more potently than apicularen B, probably due to inhibition of the V-ATPase.

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SN - 0032-0943

VL - 73

SP - 173

EP - 175

JO - Planta Medica

JF - Planta Medica

IS - 2

ER -

Inhibition of bone resorption in cultures of mouse calvariae by apicularen A

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