Inhibition of human immunodeficiency virus infection of human lymphocytes by gangliosides

Hideki Nakakuma, Tatsuya Kawaguchi, Atsushi Koito, Toshio Hattori, Tadashi Kagimoto, Kiyoshi Takatsuki

Research output: Contribution to journalArticlepeer-review


As the first step in human immunodeficiency virus (HIV) infection, HIV binds to CD4 molecules on the surface of human T lymphocytes. Expression of CD4 by the cells is remarkably modulated by exogenously added gangliosides, which are normal components of the surface of animal cells. We report here that these physiological molecules also clearly inhibited HIV infection of lymphocytes in vitro in a dose-dependent manner through the selective modulation of CD4 from the cell surface. This raises the possibility of in vivo application of gangliosides as a new strategy for treating acquired immunodeficiency syndrome.

Original languageEnglish
Pages (from-to)702-705
Number of pages4
JournalJapanese Journal of Cancer Research
Issue number8
Publication statusPublished - 1989 Aug


  • CD4
  • Ganglioside
  • Human immunodeficiency virus

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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