Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2

Yuki Yoshino; Manami Suzuki; Hidekazu Takahashi; Chikashi Ishioka

doi:10.1016/j.bbrc.2015.06.142

Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2

Yuki Yoshino, Manami Suzuki, Hidekazu Takahashi, Chikashi Ishioka

Tohoku University

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Cancer cell invasion is a critical phenomenon in cancer pathogenesis. Glycogen synthase kinase-3β (GSK-3β) has been reported to regulate cancer cell invasion both negatively and positively. Thus, the net effect of GSK-3β on invasion is unclear. In this report, we showed that GSK-3β inhibitors induced dysregulation of the actin cytoskeleton and functional insufficiency of focal adhesion, which resulted in suppressed invasion. In addition, WAVE2, an essential molecule for actin fibre branching, was down-regulated after GSK-3β inhibition. Collectively, we propose that the WAVE2-actin cytoskeleton axis is an important target of GSK-3β inhibitors in cancer cell invasion.

Original language	English
Pages (from-to)	275-280
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	464
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2015.06.142
Publication status	Published - 2015 Jul 20

Keywords

Actin cytoskeleton
Focal adhesion
GSK-3β
WAVE2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bbrc.2015.06.142

Cite this

@article{dd246f60b3f54535b03226c6878445be,

title = "Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2",

abstract = "Cancer cell invasion is a critical phenomenon in cancer pathogenesis. Glycogen synthase kinase-3β (GSK-3β) has been reported to regulate cancer cell invasion both negatively and positively. Thus, the net effect of GSK-3β on invasion is unclear. In this report, we showed that GSK-3β inhibitors induced dysregulation of the actin cytoskeleton and functional insufficiency of focal adhesion, which resulted in suppressed invasion. In addition, WAVE2, an essential molecule for actin fibre branching, was down-regulated after GSK-3β inhibition. Collectively, we propose that the WAVE2-actin cytoskeleton axis is an important target of GSK-3β inhibitors in cancer cell invasion.",

keywords = "Actin cytoskeleton, Focal adhesion, GSK-3β, WAVE2",

author = "Yuki Yoshino and Manami Suzuki and Hidekazu Takahashi and Chikashi Ishioka",

note = "Funding Information: This study was supported in part by the Ministry of Education, Culture, Sports, Science and Technology, Japan. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc. All rights reserved.",

year = "2015",

month = jul,

day = "20",

doi = "10.1016/j.bbrc.2015.06.142",

language = "English",

volume = "464",

pages = "275--280",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "1",

}

Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2. / Yoshino, Yuki; Suzuki, Manami; Takahashi, Hidekazu et al.
In: Biochemical and Biophysical Research Communications, Vol. 464, No. 1, 20.07.2015, p. 275-280.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2

AU - Yoshino, Yuki

AU - Suzuki, Manami

AU - Takahashi, Hidekazu

AU - Ishioka, Chikashi

PY - 2015/7/20

Y1 - 2015/7/20

N2 - Cancer cell invasion is a critical phenomenon in cancer pathogenesis. Glycogen synthase kinase-3β (GSK-3β) has been reported to regulate cancer cell invasion both negatively and positively. Thus, the net effect of GSK-3β on invasion is unclear. In this report, we showed that GSK-3β inhibitors induced dysregulation of the actin cytoskeleton and functional insufficiency of focal adhesion, which resulted in suppressed invasion. In addition, WAVE2, an essential molecule for actin fibre branching, was down-regulated after GSK-3β inhibition. Collectively, we propose that the WAVE2-actin cytoskeleton axis is an important target of GSK-3β inhibitors in cancer cell invasion.

AB - Cancer cell invasion is a critical phenomenon in cancer pathogenesis. Glycogen synthase kinase-3β (GSK-3β) has been reported to regulate cancer cell invasion both negatively and positively. Thus, the net effect of GSK-3β on invasion is unclear. In this report, we showed that GSK-3β inhibitors induced dysregulation of the actin cytoskeleton and functional insufficiency of focal adhesion, which resulted in suppressed invasion. In addition, WAVE2, an essential molecule for actin fibre branching, was down-regulated after GSK-3β inhibition. Collectively, we propose that the WAVE2-actin cytoskeleton axis is an important target of GSK-3β inhibitors in cancer cell invasion.

KW - Actin cytoskeleton

KW - Focal adhesion

KW - GSK-3β

KW - WAVE2

UR - http://www.scopus.com/inward/record.url?scp=84937635780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937635780&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2015.06.142

DO - 10.1016/j.bbrc.2015.06.142

M3 - Article

C2 - 26116771

AN - SCOPUS:84937635780

SN - 0006-291X

VL - 464

SP - 275

EP - 280

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this