Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis

Hirohiko Matsumoto; Tetsuro Yamane; Masao Inagake; Hirohisa Nakatani; Yasushi Iwata; Toshio Takahashi; Hiroshi Nishimura; Hoyoku Nishino; Kiyotaka Nakagawa; Teruo Miyazawa

doi:10.1016/0304-3835(96)04248-6

Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis

Hirohiko Matsumoto, Tetsuro Yamane, Masao Inagake, Hirohisa Nakatani, Yasushi Iwata, Toshio Takahashi, Hiroshi Nishimura, Hoyoku Nishino, Kiyotaka Nakagawa, Teruo Miyazawa

Kyoto Prefectural University of Medicine

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Phosphatidylcholine hydroperoxide (PCOOH) measured using a chemiluminescence detector to examine colonic mucosal lipid hyperoxidation increased after injection of 1,2-dimethylhydrazine and green tea extract (GTE), which we previously showed inhibited carcinogenesis and oxidative DNA damage in the gastrointestinal tract. Therefore, the hyperoxidation of membrane phospholipids reflected well the degree of DNA damage and carcinogenic alteration, and may be a useful intermediate biomarker for initiation of carcinogenesis.

Original language	English
Pages (from-to)	205-209
Number of pages	5
Journal	Cancer Letters
Volume	104
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(96)04248-6
Publication status	Published - 1996 Jul 12

Keywords

1,2-Dimethylhydrazine
Chemiluminescence
Green tea extract
Intermediate biomarker
Phosphatidylcholine hydroperoxide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0304-3835(96)04248-6

Cite this

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title = "Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis",

abstract = "Phosphatidylcholine hydroperoxide (PCOOH) measured using a chemiluminescence detector to examine colonic mucosal lipid hyperoxidation increased after injection of 1,2-dimethylhydrazine and green tea extract (GTE), which we previously showed inhibited carcinogenesis and oxidative DNA damage in the gastrointestinal tract. Therefore, the hyperoxidation of membrane phospholipids reflected well the degree of DNA damage and carcinogenic alteration, and may be a useful intermediate biomarker for initiation of carcinogenesis.",

keywords = "1,2-Dimethylhydrazine, Chemiluminescence, Green tea extract, Intermediate biomarker, Phosphatidylcholine hydroperoxide",

author = "Hirohiko Matsumoto and Tetsuro Yamane and Masao Inagake and Hirohisa Nakatani and Yasushi Iwata and Toshio Takahashi and Hiroshi Nishimura and Hoyoku Nishino and Kiyotaka Nakagawa and Teruo Miyazawa",

note = "Funding Information: This study was supported by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare of Japan.",

year = "1996",

month = jul,

day = "12",

doi = "10.1016/0304-3835(96)04248-6",

language = "English",

volume = "104",

pages = "205--209",

journal = "Cancer Letters",

issn = "0304-3835",

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T1 - Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis

AU - Matsumoto, Hirohiko

AU - Yamane, Tetsuro

AU - Inagake, Masao

AU - Nakatani, Hirohisa

AU - Iwata, Yasushi

AU - Takahashi, Toshio

AU - Nishimura, Hiroshi

AU - Nishino, Hoyoku

AU - Nakagawa, Kiyotaka

AU - Miyazawa, Teruo

N1 - Funding Information: This study was supported by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare of Japan.

PY - 1996/7/12

Y1 - 1996/7/12

N2 - Phosphatidylcholine hydroperoxide (PCOOH) measured using a chemiluminescence detector to examine colonic mucosal lipid hyperoxidation increased after injection of 1,2-dimethylhydrazine and green tea extract (GTE), which we previously showed inhibited carcinogenesis and oxidative DNA damage in the gastrointestinal tract. Therefore, the hyperoxidation of membrane phospholipids reflected well the degree of DNA damage and carcinogenic alteration, and may be a useful intermediate biomarker for initiation of carcinogenesis.

AB - Phosphatidylcholine hydroperoxide (PCOOH) measured using a chemiluminescence detector to examine colonic mucosal lipid hyperoxidation increased after injection of 1,2-dimethylhydrazine and green tea extract (GTE), which we previously showed inhibited carcinogenesis and oxidative DNA damage in the gastrointestinal tract. Therefore, the hyperoxidation of membrane phospholipids reflected well the degree of DNA damage and carcinogenic alteration, and may be a useful intermediate biomarker for initiation of carcinogenesis.

KW - 1,2-Dimethylhydrazine

KW - Chemiluminescence

KW - Green tea extract

KW - Intermediate biomarker

KW - Phosphatidylcholine hydroperoxide

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DO - 10.1016/0304-3835(96)04248-6

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C2 - 8665489

AN - SCOPUS:0029973092

SN - 0304-3835

VL - 104

SP - 205

EP - 209

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Inhibition of mucosal lipid hyperoxidation by green tea extract in 1,2-dimethylhydrazine-induced rat colonic carcinogenesis

Abstract

Keywords

UN SDGs

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