Inhibition of restriction enzymes EcoRI, BamHI and HindIII by phenethylphenylphthalimides derived from thalidomide

Kazunori Motoshima; Minoru Ishikawa; Yuichi Hashimoto; Kazuyuki Sugita

doi:10.1248/cpb.59.880

Inhibition of restriction enzymes EcoRI, BamHI and HindIII by phenethylphenylphthalimides derived from thalidomide

Kazunori Motoshima, Minoru Ishikawa, Yuichi Hashimoto, Kazuyuki Sugita

LIF - Molecular and Chemical Life Science

The University of Tokyo

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We discovered inhibitors of the restriction enzymes EcoRI, BamHI and HindIII by screening our library of compounds with a phenethylphenylphthalimide skeleton, based on α-glucosidase inhibitors and liver X receptor antagonists derived from thalidomide. Structural development afforded the potent restriction enzyme inhibitors 25 and 26.

Original language	English
Pages (from-to)	880-884
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	59
Issue number	7
DOIs	https://doi.org/10.1248/cpb.59.880
Publication status	Published - 2011 Jul

Keywords

Endonuclease
Enzyme inhibitor
Phthalimide
Restriction enzyme

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abstract = "We discovered inhibitors of the restriction enzymes EcoRI, BamHI and HindIII by screening our library of compounds with a phenethylphenylphthalimide skeleton, based on α-glucosidase inhibitors and liver X receptor antagonists derived from thalidomide. Structural development afforded the potent restriction enzyme inhibitors 25 and 26.",

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AU - Motoshima, Kazunori

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AU - Hashimoto, Yuichi

AU - Sugita, Kazuyuki

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KW - Endonuclease

KW - Enzyme inhibitor

KW - Phthalimide

KW - Restriction enzyme

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Inhibition of restriction enzymes EcoRI, BamHI and HindIII by phenethylphenylphthalimides derived from thalidomide

Abstract

Keywords

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