TY - JOUR
T1 - Inhibitory effect of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of the rat
AU - Okamoto, Hiroshi
AU - Miyamoto, Susumu
AU - Mabuchi, Hiroshi
AU - Takeda, Ryoyu
N1 - Funding Information:
* This work has been supported in part by the Scientific Research Fund of the Ministry of Education of Japan and by a grant from the Tanabe Amino Acid Research Foundation.
PY - 1974/7/24
Y1 - 1974/7/24
N2 - Influence of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of rats was studied. Glucose, in high concentration (15 mM), stimulated insulin release for 30 min after incubation (the first phase), followed by distinctly increasing release during the subsequent 60 min (the second phase). Addition of 12 mM quinaldic acid to an incubation medium containing 15 mM glucose caused almost complete inhibition in the second phase of glucose-induced insulin release, while the first phase was insensitive to quinaldic acid. A possible mechanism concerning the effect of quinaldic acid on β-cells of Langerhans islets is discussed.
AB - Influence of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of rats was studied. Glucose, in high concentration (15 mM), stimulated insulin release for 30 min after incubation (the first phase), followed by distinctly increasing release during the subsequent 60 min (the second phase). Addition of 12 mM quinaldic acid to an incubation medium containing 15 mM glucose caused almost complete inhibition in the second phase of glucose-induced insulin release, while the first phase was insensitive to quinaldic acid. A possible mechanism concerning the effect of quinaldic acid on β-cells of Langerhans islets is discussed.
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U2 - 10.1016/S0006-291X(74)80025-2
DO - 10.1016/S0006-291X(74)80025-2
M3 - Article
C2 - 4368820
AN - SCOPUS:0016137888
SN - 0006-291X
VL - 59
SP - 623
EP - 629
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -