Influence of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of rats was studied. Glucose, in high concentration (15 mM), stimulated insulin release for 30 min after incubation (the first phase), followed by distinctly increasing release during the subsequent 60 min (the second phase). Addition of 12 mM quinaldic acid to an incubation medium containing 15 mM glucose caused almost complete inhibition in the second phase of glucose-induced insulin release, while the first phase was insensitive to quinaldic acid. A possible mechanism concerning the effect of quinaldic acid on β-cells of Langerhans islets is discussed.
|Number of pages
|Biochemical and Biophysical Research Communications
|Published - 1974 Jul 24