Inhibitory effect of Ti-Ag alloy on artificial biofilm formation

Kazuko Nakajo, Masatoshi Takahashi, Masafumi Kikuchi, Yukyo Takada, Osamu Okuno, Keiichi Sasaki, Nobuhiro Takahashi

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23 Citations (Scopus)


Titanium-silver (Ti-Ag) alloy has been improved for machinability and mechanical properties, but its anti-biofilm properties have not been elucidated yet. Thus, this study aimed to evaluate the effects of Ti-Ag alloy on biofilm formation and bacterial viability in comparison with pure Ti, pure Ag and silver-palladium (Ag-Pd) alloy. Biofilm formation on the metal plates was evaluated by growing Streptococcus mutans and Streptococcus sobrinus in the presence of metal plates. Bactericidal activity was evaluated using a film contact method. There were no significant differences in biofilm formation between pure Ti, pure Ag and Ag-Pd alloy, while biofilm amounts on Ti-20% Ag and Ti-25% Ag alloys were significantly lower (p<0.05). In addition, Ti-Ag alloys and pure Ti were not bactericidal, although pure Ag and Ag-Pd alloy killed bacteria. These results suggest that Ti-20% Ag and Ti-25% Ag alloys are suitable for dental material that suppresses biofilm formation without disturbing healthy oral microflora.

Original languageEnglish
Pages (from-to)389-393
Number of pages5
JournalDental Materials Journal
Issue number3
Publication statusPublished - 2014


  • Anti-adhesion
  • Anti-biofilm
  • Antibacterial activity
  • Mutans streptococci
  • Ti-Ag alloy


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