TY - GEN
T1 - Injectable polymeric nanosheets for subretinal cell delivery
AU - Kaji, Hirokazu
AU - Suzuki, Jin
AU - Nishizawa, Matsuhiko
AU - Nagai, Nobuhiro
AU - Abe, Toshiaki
N1 - Funding Information:
Research supported by AMED and KAKENHI.
Publisher Copyright:
© 2016 IEEE.
PY - 2016/11/21
Y1 - 2016/11/21
N2 - Age-related macular degeneration (AMD) is one of the major ophthalmic diseases that cause visual impairment and blindness. Although transplantation of autologous peripheral cells has been attempted by injecting cell suspensions, limited visual improvement resulted due to the low viability of the injected cells in the subretinal tissue. We developed micropatterned polymeric nanosheets toward local delivery of retinal pigment epithelial (RPE) cells. The micropatterned nanosheet directed growth and morphogenesis of the RPE cells, and allowed for the injection of an engineered RPE monolayer through syringe needles flexibly into the subretinal space of rat eyes. Such an ultra-thin flexible carrier has the promise of a minimally invasive delivery of organized cellular structures into narrow tissue spaces.
AB - Age-related macular degeneration (AMD) is one of the major ophthalmic diseases that cause visual impairment and blindness. Although transplantation of autologous peripheral cells has been attempted by injecting cell suspensions, limited visual improvement resulted due to the low viability of the injected cells in the subretinal tissue. We developed micropatterned polymeric nanosheets toward local delivery of retinal pigment epithelial (RPE) cells. The micropatterned nanosheet directed growth and morphogenesis of the RPE cells, and allowed for the injection of an engineered RPE monolayer through syringe needles flexibly into the subretinal space of rat eyes. Such an ultra-thin flexible carrier has the promise of a minimally invasive delivery of organized cellular structures into narrow tissue spaces.
UR - http://www.scopus.com/inward/record.url?scp=85006943657&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006943657&partnerID=8YFLogxK
U2 - 10.1109/NANO.2016.7751465
DO - 10.1109/NANO.2016.7751465
M3 - Conference contribution
AN - SCOPUS:85006943657
T3 - 16th International Conference on Nanotechnology - IEEE NANO 2016
SP - 267
EP - 269
BT - 16th International Conference on Nanotechnology - IEEE NANO 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
Y2 - 22 August 2016 through 25 August 2016
ER -