Quinaldic acid and 8-hydroxyquinaldic acid, end-metabolites of kynurenine (1,2), were shown to cause release of insulin from isolated Langerhans islets of rats. In this respect, both kynurenic acid and xanthurenic acid were found to be somewhat less active than quinaldic acid, but L-kynurenine, 3-hydroxyl-L-kynurenine, quinolinic acid and L-tryptophan did not cause the insulin release. Possible correlation between disorder in tryptophan metabolisms directed toward the excessive formation of quinaldic acid and 8-hydroxyquinaldic acid and pathogenesis of diabetic state was discussed.
|Number of pages||7|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - 1973 Aug 21|