TY - JOUR
T1 - Insulin-releasing effect of quinaldic acid and its relatives on isolated Langerhans islets
AU - Okamoto, Hiroshi
AU - Miyamoto, Susumu
AU - Mabuchi, Hiroshi
AU - Yoneyama, Yoshimasa
AU - Takeda, Ryoyu
PY - 1973/8/21
Y1 - 1973/8/21
N2 - Quinaldic acid and 8-hydroxyquinaldic acid, end-metabolites of kynurenine (1,2), were shown to cause release of insulin from isolated Langerhans islets of rats. In this respect, both kynurenic acid and xanthurenic acid were found to be somewhat less active than quinaldic acid, but L-kynurenine, 3-hydroxyl-L-kynurenine, quinolinic acid and L-tryptophan did not cause the insulin release. Possible correlation between disorder in tryptophan metabolisms directed toward the excessive formation of quinaldic acid and 8-hydroxyquinaldic acid and pathogenesis of diabetic state was discussed.
AB - Quinaldic acid and 8-hydroxyquinaldic acid, end-metabolites of kynurenine (1,2), were shown to cause release of insulin from isolated Langerhans islets of rats. In this respect, both kynurenic acid and xanthurenic acid were found to be somewhat less active than quinaldic acid, but L-kynurenine, 3-hydroxyl-L-kynurenine, quinolinic acid and L-tryptophan did not cause the insulin release. Possible correlation between disorder in tryptophan metabolisms directed toward the excessive formation of quinaldic acid and 8-hydroxyquinaldic acid and pathogenesis of diabetic state was discussed.
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U2 - 10.1016/0006-291X(73)90606-2
DO - 10.1016/0006-291X(73)90606-2
M3 - Article
C2 - 4584024
AN - SCOPUS:0015883997
SN - 0006-291X
VL - 53
SP - 1297
EP - 1303
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -
