Insulinoma with six islet cell tumors associated with severe hypoglycemia

Saori Ishigaki, Ai Yoshihara, Rina Ohwada, Naomi Hizuka, Takashi Hatori, Toru Furukawa, Toshio Nishikawa, Osamu Isozaki, Kazue Takano

Research output: Contribution to journalArticlepeer-review


A 43-year-old woman was admitted to hospital due to loss of consciousness. Her fasting plasma glucose and serum immunoreactive insulin levels were 14 mg/dL and 5 μU/mL, respectively. She needed continuous glucose infusion to avoid hypoglycemia. A dynamic abdominal CT scan revealed two hypervascular tumors in the pancreas. A pancreatectomy was performed and her blood glucose level was normalized. The pathological examination revealed six insulinomas but we could not find either parathyroid tumors or obvious pituitary tumor, which denied the possibility of multiple endocrine neoplasia type I. However, long-term follow-up will be necessary for monitoring the development of other tumors.

Original languageEnglish
Pages (from-to)1041-1046
Number of pages6
JournalInternal Medicine
Issue number12
Publication statusPublished - 2009


  • Hypoglycemia
  • Insulinoma
  • Multifocal tumors


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