TY - JOUR
T1 - Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1
AU - Champsaur, Marine
AU - Beilke, Joshua N.
AU - Ogasawara, Kouetsu
AU - Koszinowski, Ulrich H.
AU - Jonjic, Stipan
AU - Lanier, Lewis L.
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Human tumors frequently express membrane-bound or soluble NK group 2, member D (NKG2D) ligands. This results in chronic engagement of NKG2D on the surfaces of NK and CD8+ T cells and rapid internalization of the receptor. Although it is well appreciated that this phenomenon impairs NKG2D-dependent function, careful analysis of NKG2D-independent functions in cells chronically stimulated through NKG2D is lacking. Using a mouse model of chronic NKG2D ligand expression, we show that constant exposure to NKG2D ligands does not functionally impair NK cells and CD8+ T cells in the context of viral infection.
AB - Human tumors frequently express membrane-bound or soluble NK group 2, member D (NKG2D) ligands. This results in chronic engagement of NKG2D on the surfaces of NK and CD8+ T cells and rapid internalization of the receptor. Although it is well appreciated that this phenomenon impairs NKG2D-dependent function, careful analysis of NKG2D-independent functions in cells chronically stimulated through NKG2D is lacking. Using a mouse model of chronic NKG2D ligand expression, we show that constant exposure to NKG2D ligands does not functionally impair NK cells and CD8+ T cells in the context of viral infection.
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U2 - 10.4049/jimmunol.1000397
DO - 10.4049/jimmunol.1000397
M3 - Article
C2 - 20530257
AN - SCOPUS:77956206286
SN - 0022-1767
VL - 185
SP - 157
EP - 165
JO - Journal of Immunology
JF - Journal of Immunology
IS - 1
ER -