Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the β-oxidation system in rat liver

Tsuyoshi Tsuduki, Yumiko Nakamura, Taro Honma, Kiyotaka Nakagawa, Toshiyuki Kimura, Ikuo Ikeda, Teruo Miyazawa

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)

Abstract

It was recently shown that administration of 1-deoxynojirimycin (DNJ) extracted from mulberry suppresses an increase in postprandial blood glucose in humans. These findings are of interest, but other physiological functions of DNJ are unknown. This study examined the effects of oral administration of DNJ (1 mg/kg of body weight/day) or mulberry extracts enriched in DNJ (meDNJ; 100 or 200 mg of extract/kg of body weight/day, equivalent to 0.53 or 1.06 mg of DNJ/ kg of body weight/day) In male Sprague - Dawley rats for 4 weeks. DNJ and meDNJ enhanced expression of adiponectin mRNA in white adipose tissue; increased plasma adiponectin levels, enhanced expression of AMPK mRNA, activated the β-oxidation system, and suppressed lipid accumulation In the liver. Intake of DNJ and meDNJ did not cause hepatic dysfunction and led to a reduction of oxidative stress. These results indicate the efficacy and safety of DNJ and meDNJ.

Original languageEnglish
Pages (from-to)11024-11029
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume57
Issue number22
DOIs
Publication statusPublished - 2009 Nov 25

Keywords

  • β-oxidation
  • Adiponectin
  • AMPK
  • Deoxynojirimycin
  • Mulberry
  • Rat

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