TY - JOUR
T1 - Intake of conjugated eicosapentaenoic acid suppresses lipid accumulation in liver and epididymal adipose tissue in rats
AU - Tsuzuki, Tsuyoshi
AU - Kawakami, Yuki
AU - Suzuki, Yoshihiro
AU - Abe, Renpei
AU - Nakagawa, Kiyotaka
AU - Miyazawa, Teruo
PY - 2005/11
Y1 - 2005/11
N2 - It has been reported that consumption of CLA and EPA alters lipid metabolism. CLA contains conjugated double bonds, and EPA is an n-3 PUFA. Based on the possibility that a molecule with both of these structures might have interesting physiological effects, we prepared conjugated FA from EPA by alkaline isomerization and examined the effects of the conjugated EPA (CEPA) on lipid metabolism in rats. Rats were fed by oral gavage every day for 4 wk with 200 mg of FA including linoleic acid, EPA, CLA, or CEPA. Compared with other groups, rats fed CEPA showed a significant weight loss in epididymal adipose tissue and significant decreases in the levels of liver TAG and total cholesterol (TC), indicating reduced accumulation of lipid in the liver and adipose tissue. The plasma levels of TAG, TC, FFA, and tumor necrosis factor-α in rats fed CEPA were reduced, as was the activity of the FA synthesis system in the liver, whereas the FA-β-oxidation system was activated by CEPA. These results suggest that intake of CEPA suppresses lipid accumulation in the liver and epididymal adipose tissue while increasing lipid catabolism in rats.
AB - It has been reported that consumption of CLA and EPA alters lipid metabolism. CLA contains conjugated double bonds, and EPA is an n-3 PUFA. Based on the possibility that a molecule with both of these structures might have interesting physiological effects, we prepared conjugated FA from EPA by alkaline isomerization and examined the effects of the conjugated EPA (CEPA) on lipid metabolism in rats. Rats were fed by oral gavage every day for 4 wk with 200 mg of FA including linoleic acid, EPA, CLA, or CEPA. Compared with other groups, rats fed CEPA showed a significant weight loss in epididymal adipose tissue and significant decreases in the levels of liver TAG and total cholesterol (TC), indicating reduced accumulation of lipid in the liver and adipose tissue. The plasma levels of TAG, TC, FFA, and tumor necrosis factor-α in rats fed CEPA were reduced, as was the activity of the FA synthesis system in the liver, whereas the FA-β-oxidation system was activated by CEPA. These results suggest that intake of CEPA suppresses lipid accumulation in the liver and epididymal adipose tissue while increasing lipid catabolism in rats.
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U2 - 10.1007/s11745-005-1475-0
DO - 10.1007/s11745-005-1475-0
M3 - Article
C2 - 16459923
AN - SCOPUS:29444448615
SN - 0024-4201
VL - 40
SP - 1117
EP - 1123
JO - Lipids
JF - Lipids
IS - 11
M1 - L9815
ER -