TY - JOUR
T1 - Intercellular adhesion molecule 1-dependent activation of interleukin 8 expression in Candida albicans-infected human gingival epithelial cells
AU - Egusa, Hiroshi
AU - Nikawa, Hiroki
AU - Makihira, Seicho
AU - Jewett, Anahid
AU - Yatani, Hirofumi
AU - Hamada, Taizo
PY - 2005/1
Y1 - 2005/1
N2 - Increased induction of interleukin 8 (IL-8) and intercellular adhesion molecule 1 (ICAM-1) by oral epithelial cells may play a role in the host defense mechanism in oropharyngeal candidiasis; however, little is known about the expression feature of these molecules on human gingival epithelial cells (HGECs) during Candida albicans infection. In this report we present evidence that neutralization with antibody against ICAM-1 inhibited both the adherence of C. albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans.
AB - Increased induction of interleukin 8 (IL-8) and intercellular adhesion molecule 1 (ICAM-1) by oral epithelial cells may play a role in the host defense mechanism in oropharyngeal candidiasis; however, little is known about the expression feature of these molecules on human gingival epithelial cells (HGECs) during Candida albicans infection. In this report we present evidence that neutralization with antibody against ICAM-1 inhibited both the adherence of C. albicans to HGECs and the Candida-induced production of IL-8, suggesting a role for ICAM-1 in recognition and signaling in HGECs to express IL-8 upon infection with C. albicans.
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UR - http://www.scopus.com/inward/citedby.url?scp=11144278240&partnerID=8YFLogxK
U2 - 10.1128/IAI.73.1.622-626.2005
DO - 10.1128/IAI.73.1.622-626.2005
M3 - Article
C2 - 15618204
AN - SCOPUS:11144278240
SN - 0019-9567
VL - 73
SP - 622
EP - 626
JO - Infection and Immunity
JF - Infection and Immunity
IS - 1
ER -
