TY - JOUR
T1 - Interferon-α significantly reduces cerebrospinal fluid CD4 cell subsets in HAM/TSP
AU - Feng, Juan
AU - Misu, Tatsuro
AU - Fujihara, Kazuo
AU - Saito, Hiroshi
AU - Takahashi, Toshiaki
AU - Kohnosu, Takeshi
AU - Shiga, Yusei
AU - Takeda, Atsushi
AU - Sato, Shigeru
AU - Takase, Sadao
AU - Itoyama, Yasuto
N1 - Funding Information:
The authors thank Mr. Brent Bell for reading the manuscript. This work was supported by grants-in-aid for General Scientific Research (13470131 and 13670626) from the Ministry of Education, Science, Culture, Science and Technology, a grant from the Neuroimmunological Research Committee and the Tawara's Endowment for HAM Research.
PY - 2003/8
Y1 - 2003/8
N2 - We, for the first time, analyzed T cell and natural killer (NK) cell subsets in the cerebrospinal fluid (CSF) in nine patients with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) treated with interferon-α (IFN-α). The CD4/ CD8 ratio in CSF was significantly lower after the therapy, which is mainly attributable to the significant reduction in CD4+ cells, especially CD25+CD4 and CD45RO+CD4 cell subsets. Meanwhile, NK, natural T and NKT cell subsets in the CSF remained unchanged. There was no CSF lymphocyte subset significantly associated with the clinical efficacy of IFN-α in this small-scale study, and more patients should be analyzed to ascertain the link.
AB - We, for the first time, analyzed T cell and natural killer (NK) cell subsets in the cerebrospinal fluid (CSF) in nine patients with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) treated with interferon-α (IFN-α). The CD4/ CD8 ratio in CSF was significantly lower after the therapy, which is mainly attributable to the significant reduction in CD4+ cells, especially CD25+CD4 and CD45RO+CD4 cell subsets. Meanwhile, NK, natural T and NKT cell subsets in the CSF remained unchanged. There was no CSF lymphocyte subset significantly associated with the clinical efficacy of IFN-α in this small-scale study, and more patients should be analyzed to ascertain the link.
KW - Cerebrospinal fluid
KW - HTLV-I associated myelopathy
KW - Interferon-α
KW - Lymphocyte subsets
KW - Therapy
KW - Tropical spastic paraparesis
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U2 - 10.1016/S0165-5728(03)00219-4
DO - 10.1016/S0165-5728(03)00219-4
M3 - Article
C2 - 12965269
AN - SCOPUS:18844465876
SN - 0165-5728
VL - 141
SP - 170
EP - 173
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -