Interferon-α significantly reduces cerebrospinal fluid CD4 cell subsets in HAM/TSP

Juan Feng, Tatsuro Misu, Kazuo Fujihara, Hiroshi Saito, Toshiaki Takahashi, Takeshi Kohnosu, Yusei Shiga, Atsushi Takeda, Shigeru Sato, Sadao Takase, Yasuto Itoyama

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14 Citations (Scopus)


We, for the first time, analyzed T cell and natural killer (NK) cell subsets in the cerebrospinal fluid (CSF) in nine patients with human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) treated with interferon-α (IFN-α). The CD4/ CD8 ratio in CSF was significantly lower after the therapy, which is mainly attributable to the significant reduction in CD4+ cells, especially CD25+CD4 and CD45RO+CD4 cell subsets. Meanwhile, NK, natural T and NKT cell subsets in the CSF remained unchanged. There was no CSF lymphocyte subset significantly associated with the clinical efficacy of IFN-α in this small-scale study, and more patients should be analyzed to ascertain the link.

Original languageEnglish
Pages (from-to)170-173
Number of pages4
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - 2003 Aug


  • Cerebrospinal fluid
  • HTLV-I associated myelopathy
  • Interferon-α
  • Lymphocyte subsets
  • Therapy
  • Tropical spastic paraparesis


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