Intracellular Electrochemical Sensing

Kosuke Ino, Yuji Nashimoto, Noriko Taira, Javier Ramon Azcon, Hitoshi Shiku

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)


Observing biochemical processes within living cell is imperative for biological and medical research. Fluoresce imaging is widely used for intracellular sensing of cell membranes, nuclei, lysosomes, and pH. Electrochemical assays have been proposed as an alternative to fluorescence-based assays because of excellent analytical features of electrochemical devices. Notably, thanks to the rapid progress of micro/nanotechnologies and electrochemical techniques, intracellular electrochemical sensing is making rapid progress, leading to a successful detection of intracellular components. Such insight can provide a deep understanding of cellular biological processes and, ultimately, define the human healthy and diseased states. In this review, we present an overview of recent research progress in intracellular electrochemical sensing. We focus on two main topics, electrochemical extraction of cytosolic contents from cells and intracellular electrochemical sensing in situ.

Original languageEnglish
Pages (from-to)2195-2209
Number of pages15
Issue number10
Publication statusPublished - 2018 Oct


  • Analytical electrochemistry
  • Cell analysis
  • Intracellular sensing
  • Micro/nanoelectrode


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