@article{7dfecf6513c34329aa21c489a8ee700b,
title = "Intracholecystic papillary neoplasm arising in the cystic duct and extending into common bile duct: a case report",
abstract = "An 83-year-old man without specific symptoms was referred to our hospital for further evaluation and treatment of apparent double primary tumors of the cystic duct and common bile duct. Computed tomography showed contrast-enhanced solid tumors in the cystic duct and common bile duct. Magnetic resonance imaging showed that the bile duct tumor was isointense on T1-weighted images and had low intensity on T2-weighted images. In addition, the bile duct tumor showed high intensity on diffusion-weighted images. Endoscopic ultrasonography revealed the tumor of the common bile duct and endoscopic retrograde cholangiopancreatography demonstrated a filling defect in the bile duct. The cystic duct was not identified on endoscopic ultrasonography or endoscopic retrograde cholangiopancreatography. Transpapillary biopsy of the bile duct tumor showed adenocarcinoma. The patient was diagnosed with double primary tumors of the cystic duct and the common bile duct and underwent subtotal stomach-preserving pancreaticoduodenectomy. Microscopic examination with molecular profiling of the tumors revealed a high-grade noninvasive intracholecystic papillary neoplasm of the cystic duct extending into the common bile duct and forming a tubulopapillary neoplasm with invasion of the common bile duct.",
keywords = "ICPN (intracholecystic papillary neoplasm), IPNB (intraductal papillary neoplasm of bile duct), Intraepithelial progression, Invasion",
author = "Masahiro Iseki and Masamichi Mizuma and Yasutaka Aoki and Shuichi Aoki and Tatsuo Hata and Tatsuyuki Takadate and Kei Kawaguchi and Kunihiro Masuda and Masaharu Ishida and Hideo Ohtsuka and Kei Nakagawa and Hiroki Hayashi and Takanori Morikawa and Takashi Kamei and Kiyoshi Kume and Atsushi Kanno and Atsushi Masamune and Yuko Omori and Yusuke Ono and Yusuke Mizukami and Toru Furukawa and Michiaki Unno",
note = "Funding Information: Yusuke Ono and Yusuke Mizukami received a research grant from Hitachi High-Tech Corporation. The other authors declare that they have no conflict of interest. Funding Information: This work was supported by JSPS KAKENHI Grant Number JP16H05410 to MU. We are grateful to Ms. Fumiko Date, Tohoku University Graduate School of Medicine, for her technical assistance, Ms. Yuko Hayakawa, Sapporo Higashi Tokushukai Hospital, for her technical support in the genetic analyses, and Mr. Osamu Takahashi (Thermo Fisher Scientific) for technical support regarding the sequencing analyses. We also thank Rebecca Tollefson, DVM, from Edanz Group (https://en-author-services.edanzgroup.com/ac) for editing a draft of this manuscript. Funding Information: This work was supported by JSPS KAKENHI Grant Number JP16H05410 to MU. We are grateful to Ms. Fumiko Date, Tohoku University Graduate School of Medicine, for her technical assistance, Ms. Yuko Hayakawa, Sapporo Higashi Tokushukai Hospital, for her technical support in the genetic analyses, and Mr. Osamu Takahashi (Thermo Fisher Scientific) for technical support regarding the sequencing analyses. We also thank Rebecca Tollefson, DVM, from Edanz Group ( https://en-author-services.edanzgroup.com/ac ) for editing a draft of this manuscript. Publisher Copyright: {\textcopyright} 2021, Japanese Society of Gastroenterology.",
year = "2021",
month = apr,
doi = "10.1007/s12328-020-01311-4",
language = "English",
volume = "14",
pages = "668--677",
journal = "Clinical Journal of Gastroenterology",
issn = "1865-7257",
publisher = "Springer Japan",
number = "2",
}