Intracrine mechanism of estrogen synthesis in breast cancer

Takashi Suzuki; Takuya Moriya; Takanori Ishida; Noriaki Ohuchi; Hironobu Sasano

doi:10.1016/j.biopha.2003.09.007

Intracrine mechanism of estrogen synthesis in breast cancer

Takashi Suzuki, Takuya Moriya, Takanori Ishida, Noriaki Ohuchi, Hironobu Sasano

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

It has been demonstrated that biologically active estrogens are locally produced from circulating inactive steroids in an intracrine mechanism in the breast carcinoma. The in situ production of estrogens is considered to play an important role in the proliferation of breast cancer cells, especially in the postmenopausal women. Therefore, the total blockade of this pathway may lead to an improvement in the prognosis in breast cancer patients due to the inhibition of estrogenic actions. In this review, we describe the recent studies of enzymes related to intracrine mechanism of estrogen synthesis, including aromatase, steroid sulfatase (STS), and 17β-hydroxysteroid dehydrogenase, in human breast carcinoma tissues, and discuss the biological significance of local production of estrogens in human breast cancer.

Original language	English
Pages (from-to)	460-462
Number of pages	3
Journal	Biomedicine and Pharmacotherapy
Volume	57
Issue number	10
DOIs	https://doi.org/10.1016/j.biopha.2003.09.007
Publication status	Published - 2003 Dec

Keywords

Breast carcinoma
Estrogen
Intracrine

ASJC Scopus subject areas

Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biopha.2003.09.007

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title = "Intracrine mechanism of estrogen synthesis in breast cancer",

abstract = "It has been demonstrated that biologically active estrogens are locally produced from circulating inactive steroids in an intracrine mechanism in the breast carcinoma. The in situ production of estrogens is considered to play an important role in the proliferation of breast cancer cells, especially in the postmenopausal women. Therefore, the total blockade of this pathway may lead to an improvement in the prognosis in breast cancer patients due to the inhibition of estrogenic actions. In this review, we describe the recent studies of enzymes related to intracrine mechanism of estrogen synthesis, including aromatase, steroid sulfatase (STS), and 17β-hydroxysteroid dehydrogenase, in human breast carcinoma tissues, and discuss the biological significance of local production of estrogens in human breast cancer.",

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author = "Takashi Suzuki and Takuya Moriya and Takanori Ishida and Noriaki Ohuchi and Hironobu Sasano",

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T1 - Intracrine mechanism of estrogen synthesis in breast cancer

AU - Suzuki, Takashi

AU - Moriya, Takuya

AU - Ishida, Takanori

AU - Ohuchi, Noriaki

AU - Sasano, Hironobu

PY - 2003/12

Y1 - 2003/12

N2 - It has been demonstrated that biologically active estrogens are locally produced from circulating inactive steroids in an intracrine mechanism in the breast carcinoma. The in situ production of estrogens is considered to play an important role in the proliferation of breast cancer cells, especially in the postmenopausal women. Therefore, the total blockade of this pathway may lead to an improvement in the prognosis in breast cancer patients due to the inhibition of estrogenic actions. In this review, we describe the recent studies of enzymes related to intracrine mechanism of estrogen synthesis, including aromatase, steroid sulfatase (STS), and 17β-hydroxysteroid dehydrogenase, in human breast carcinoma tissues, and discuss the biological significance of local production of estrogens in human breast cancer.

AB - It has been demonstrated that biologically active estrogens are locally produced from circulating inactive steroids in an intracrine mechanism in the breast carcinoma. The in situ production of estrogens is considered to play an important role in the proliferation of breast cancer cells, especially in the postmenopausal women. Therefore, the total blockade of this pathway may lead to an improvement in the prognosis in breast cancer patients due to the inhibition of estrogenic actions. In this review, we describe the recent studies of enzymes related to intracrine mechanism of estrogen synthesis, including aromatase, steroid sulfatase (STS), and 17β-hydroxysteroid dehydrogenase, in human breast carcinoma tissues, and discuss the biological significance of local production of estrogens in human breast cancer.

KW - Breast carcinoma

KW - Estrogen

KW - Intracrine

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JO - Biomedicine and Pharmacotherapy

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ER -

Intracrine mechanism of estrogen synthesis in breast cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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