Intraductal spread of carcinoma: a risk for breast conserving surgery

N. Ohuchi, A. Furuta, S. Mori

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Intraductal spread of carcinoma (ISC) was defined as "DCIS clearly present extending beyond terminal duct-lobular unit, or present prominently within large ducts," using a sequential slicing of tissues and 3-D reconstruction of tumors. We then analyzed the relationship between ISC in specimens obtained by breast conserving surgery (BCS) and carcinoma residue in specimens obtained by total mastectomy. We found a strong correlation between the ISC factor in BCS tissues and the carcinoma residue in mastectomy specimens. Among 12 patients under observation without mastectomy, 3 patients subsequently developed breast carcinoma. Two of the 3 patients demonstrated ISC in BCS specimens. One of 10 patients without ISC, however, developed carcinoma, suggesting that the ISC is a risk factor in breast conserving surgery for breast cancer patients.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume21 Suppl 2
Publication statusPublished - 1994 Jun

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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