Intramembranous fine deposit disease associated with collagen disorders: a new morphological entity?

Hiroshi Sato, Takao Saito, Kaoru Yoshinaga

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15 Citations (Scopus)


A distinct, hitherto unknown renal histopathological appearance, consisting of diffuse thickening of the glomerular basement membrane (GBM) with fine intramembranous electron-dense deposits, was observed in the renal biopsies from three patients with collagen diseases. In each case, proteinuria was mild with normal urinary sediment. On light microscopy there were no particular abnormalities but a mild thickening of the glomerular capillary wall. Immunofluorescence studies revealed faint linear or extremely fine granular IgG deposition along the capillary wall. On electron microscopy, the GBM was diffusely thickened with fine intramembranous electron-dense deposits without spike formation. No other deposits were seen in the glomerulus. These histological features resembled those of membranous glomerulonephritis (MGN), although the possibility of the early change of MGN is excluded by specific findings in these cases. Other GBM-thickening diseases such as diabetic glomerulosclerosis were ruled out clinically and histologically. Our cases have a singular renal histopathology which differs from any of the previously established classifications of glomerular lesions. It may be a specific change associated with some type of collagen disease.

Original languageEnglish
Pages (from-to)447-451
Number of pages5
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Issue number5
Publication statusPublished - 1992 Sept
Externally publishedYes


  • Collagen disease
  • Glomerular basement membrane
  • Intramembranous deposit
  • Membranous glomerulonephritis
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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