Intrauterine Candida albicans infection elicits severe inflammation in fetal sheep

Matthew S. Payne, Matthew W. Kemp, Suhas G. Kallapur, Paranthaman Senthamarai Kannan, Masatoshi Saito, Yuichiro Miura, John P. Newnham, Sarah Stock, Demelza J. Ireland, Boris W. Kramer, Alan H. Jobe

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background:Preventing preterm birth and subsequent adverse neonatal sequelae is among the greatest clinical challenges of our time. Recent studies suggest a role for Candida spp. in preterm birth and fetal injury, as a result of their colonization of either the vagina and/or the amniotic cavity. We hypothesized that intraamniotic Candida albicans would cause a vigorous, acute fetal inflammatory response.Methods:Sheep carrying singleton pregnancies received single intraamniotic injections of either saline (control) or 10 7 colony-forming units C. albicans 1 or 2 d prior to surgical delivery and euthanasia at 124 ± 2 d gestation.Results:Colonization of the amniotic cavity by C. albicans resulted in a modest inflammatory response at 1 d and florid inflammation at 2 d, characterized by fetal thrombocytopenia, lymphopenia, and significant increases of inflammatory cytokines/chemokines in the fetal membranes skin, lung, and the amniotic fluid.Conclusion:Acute colonization of the amniotic cavity by C. albicans causes severe intrauterine inflammation and fetal injury. C. albicans is a potent fetal pathogen that can contribute to adverse pregnancy outcomes.

Original languageEnglish
Pages (from-to)716-722
Number of pages7
JournalPediatric Research
Issue number6
Publication statusPublished - 2014 Jun


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