Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias

Mitsue Inomata; Shinichiro Takahashi; Hideo Harigae; Junichi Kameoka; Mitsuo Kaku; Takeshi Sasaki

doi:10.1016/j.leukres.2005.07.015

Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias

Mitsue Inomata, Shinichiro Takahashi, Hideo Harigae, Junichi Kameoka, Mitsuo Kaku, Takeshi Sasaki

HOSP - University Hospital (not affiliated with any section)

Tohoku University

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), playing a role in leukemogenesis while decreased expression of PU.1 induces AML in mice model. Therefore, we speculated that there is an inverse relationship between these two factors. To clarify this, we measured the expression level of Flt3 and PU.1 in 24 primary AML specimens. As a result, there is a significant negative correlation between Flt3 and PU.1 (r = -0.43, p < 0.05). Furthermore, we revealed that flt3 gene promoter is suppressed by the over-expression of PU.1, suggesting that PU.1 is a potential suppressor of flt3 gene promoter.

Original language	English
Pages (from-to)	659-664
Number of pages	6
Journal	Leukemia Research
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.leukres.2005.07.015
Publication status	Published - 2006 Jun

Keywords

AML
Flt3
PU.1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2005.07.015

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title = "Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias",

abstract = "Over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), playing a role in leukemogenesis while decreased expression of PU.1 induces AML in mice model. Therefore, we speculated that there is an inverse relationship between these two factors. To clarify this, we measured the expression level of Flt3 and PU.1 in 24 primary AML specimens. As a result, there is a significant negative correlation between Flt3 and PU.1 (r = -0.43, p < 0.05). Furthermore, we revealed that flt3 gene promoter is suppressed by the over-expression of PU.1, suggesting that PU.1 is a potential suppressor of flt3 gene promoter.",

keywords = "AML, Flt3, PU.1",

author = "Mitsue Inomata and Shinichiro Takahashi and Hideo Harigae and Junichi Kameoka and Mitsuo Kaku and Takeshi Sasaki",

note = "Funding Information: Authors thank for Dr. I. Ishikawa at Furukawa City Hospital and all the members in Department of Rheumatology and Hematology for helping collecting AML specimens. This work is supported in part by the Kurozumi Medical Foundation (to S.T.), MEXT.KAKENHI (17790635) (to S.T.) and Grant-in Aid from Japan Society for the Promotion of Science (to H.H. and T.S.). ",

year = "2006",

month = jun,

doi = "10.1016/j.leukres.2005.07.015",

language = "English",

volume = "30",

pages = "659--664",

journal = "Leukemia Research",

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TY - JOUR

T1 - Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias

AU - Inomata, Mitsue

AU - Takahashi, Shinichiro

AU - Harigae, Hideo

AU - Kameoka, Junichi

AU - Kaku, Mitsuo

AU - Sasaki, Takeshi

N1 - Funding Information: Authors thank for Dr. I. Ishikawa at Furukawa City Hospital and all the members in Department of Rheumatology and Hematology for helping collecting AML specimens. This work is supported in part by the Kurozumi Medical Foundation (to S.T.), MEXT.KAKENHI (17790635) (to S.T.) and Grant-in Aid from Japan Society for the Promotion of Science (to H.H. and T.S.).

PY - 2006/6

Y1 - 2006/6

N2 - Over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), playing a role in leukemogenesis while decreased expression of PU.1 induces AML in mice model. Therefore, we speculated that there is an inverse relationship between these two factors. To clarify this, we measured the expression level of Flt3 and PU.1 in 24 primary AML specimens. As a result, there is a significant negative correlation between Flt3 and PU.1 (r = -0.43, p < 0.05). Furthermore, we revealed that flt3 gene promoter is suppressed by the over-expression of PU.1, suggesting that PU.1 is a potential suppressor of flt3 gene promoter.

AB - Over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), playing a role in leukemogenesis while decreased expression of PU.1 induces AML in mice model. Therefore, we speculated that there is an inverse relationship between these two factors. To clarify this, we measured the expression level of Flt3 and PU.1 in 24 primary AML specimens. As a result, there is a significant negative correlation between Flt3 and PU.1 (r = -0.43, p < 0.05). Furthermore, we revealed that flt3 gene promoter is suppressed by the over-expression of PU.1, suggesting that PU.1 is a potential suppressor of flt3 gene promoter.

KW - AML

KW - Flt3

KW - PU.1

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C2 - 16271760

AN - SCOPUS:33645276010

SN - 0145-2126

VL - 30

SP - 659

EP - 664

JO - Leukemia Research

JF - Leukemia Research

IS - 6

ER -

Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias

Abstract

Keywords

UN SDGs

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