TY - JOUR
T1 - Investigation of macrocyclization sites for the synthesis of dendroamide A-an approach from a conformational search
AU - Matsumoto, Takatoshi
AU - Morishita, Eiichi
AU - Shioiri, Takayuki
PY - 2007/8/27
Y1 - 2007/8/27
N2 - The systematic conformational analysis of three linear precursors for the synthesis of dendroamide A has revealed that these three precursors have the distance between the N- and C-terminal in the range of 3.43-3.93 Å, which suggests the possibility of macrocyclization. This result coincides with the results of the actual synthesis of dendroamide A, but contradicts the reported calculated results.
AB - The systematic conformational analysis of three linear precursors for the synthesis of dendroamide A has revealed that these three precursors have the distance between the N- and C-terminal in the range of 3.43-3.93 Å, which suggests the possibility of macrocyclization. This result coincides with the results of the actual synthesis of dendroamide A, but contradicts the reported calculated results.
KW - Conformational analysis
KW - Cyclic peptide
KW - Dendroamide A
KW - Macrocyclization
KW - Rational synthetic strategy
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U2 - 10.1016/j.tet.2007.04.096
DO - 10.1016/j.tet.2007.04.096
M3 - Article
AN - SCOPUS:34447512668
SN - 0040-4020
VL - 63
SP - 8571
EP - 8575
JO - Tetrahedron
JF - Tetrahedron
IS - 35
ER -