Involvement of nitric oxide in orthodontic tooth movement in rats

Keigo Hayashi, Kaoru Igarashi, Kotaro Miyoshi, Hisashi Shinoda, Hideo Mitani

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Nitric oxide (NO) is an important regulatory molecule in bone formation and resorption. The purpose of this study was to examine the role of NO in orthodontic tooth movement in rats. We used specific inhibitors of NO synthases (NOS). Upper first molars of 9-week-old male Wistar rats were moved buccally for 21 days. The local administration of NG-nitro-L-arginine methyl ester·HCl (L-NAME), a general inhibitor of NOS activity, significantly reduced tooth movement. On the other hand, N6-(1-iminoethyl)-L- lysine·2HCl (L-NIL), a selective inhibitor of the inducible isoform of NOS, had no effect. These results suggest that NO is an important biochemical mediator in the response of periodontal tissue to orthodontic force and is produced primarily through the activity of constitutive NOS.

Original languageEnglish
Pages (from-to)306-309
Number of pages4
JournalAmerican Journal of Orthodontics and Dentofacial Orthopedics
Issue number3
Publication statusPublished - 2002


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