Involvement of spot 35 protein, a cerebellar protein, in modulation of Purkinje cell activity of the rat cerebellum

Shoji Maruyama; Ge Zhang; Yoshimatsu Tamura; Tohru Yamakuni; Yasuo Takahashi

doi:10.1016/0014-2999(85)90455-8

Involvement of spot 35 protein, a cerebellar protein, in modulation of Purkinje cell activity of the rat cerebellum

Shoji Maruyama, Ge Zhang, Yoshimatsu Tamura, Tohru Yamakuni, Yasuo Takahashi

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

Abstract

Spot 35 protein, applied iontophoretically, produced inhibition of spontaneous Purkinje cell activity in most cells and augmented the NE- or 5-HT-induced inhibition of spontaneous discharges whereas it hardly affected the inhibitory response of Purkinje cells to GABA, taurine, and β-alanine, and the excitatory response to glutamate. It is suggested that spot 35 protein may be involved in normal physiological operation of the cerebellum through modulation of the NE or 5-HT system.

Original language	English
Pages (from-to)	309-313
Number of pages	5
Journal	European Journal of Pharmacology
Volume	108
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(85)90455-8
Publication status	Published - 1985 Feb 5

Keywords

Amino acids
Cerebellum
Norepinephrine
Serotonin
Spot 35 protein
cGMP

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(85)90455-8

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title = "Involvement of spot 35 protein, a cerebellar protein, in modulation of Purkinje cell activity of the rat cerebellum",

abstract = "Spot 35 protein, applied iontophoretically, produced inhibition of spontaneous Purkinje cell activity in most cells and augmented the NE- or 5-HT-induced inhibition of spontaneous discharges whereas it hardly affected the inhibitory response of Purkinje cells to GABA, taurine, and β-alanine, and the excitatory response to glutamate. It is suggested that spot 35 protein may be involved in normal physiological operation of the cerebellum through modulation of the NE or 5-HT system.",

keywords = "Amino acids, Cerebellum, Norepinephrine, Serotonin, Spot 35 protein, cGMP",

author = "Shoji Maruyama and Ge Zhang and Yoshimatsu Tamura and Tohru Yamakuni and Yasuo Takahashi",

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T1 - Involvement of spot 35 protein, a cerebellar protein, in modulation of Purkinje cell activity of the rat cerebellum

AU - Maruyama, Shoji

AU - Zhang, Ge

AU - Tamura, Yoshimatsu

AU - Yamakuni, Tohru

AU - Takahashi, Yasuo

PY - 1985/2/5

Y1 - 1985/2/5

N2 - Spot 35 protein, applied iontophoretically, produced inhibition of spontaneous Purkinje cell activity in most cells and augmented the NE- or 5-HT-induced inhibition of spontaneous discharges whereas it hardly affected the inhibitory response of Purkinje cells to GABA, taurine, and β-alanine, and the excitatory response to glutamate. It is suggested that spot 35 protein may be involved in normal physiological operation of the cerebellum through modulation of the NE or 5-HT system.

AB - Spot 35 protein, applied iontophoretically, produced inhibition of spontaneous Purkinje cell activity in most cells and augmented the NE- or 5-HT-induced inhibition of spontaneous discharges whereas it hardly affected the inhibitory response of Purkinje cells to GABA, taurine, and β-alanine, and the excitatory response to glutamate. It is suggested that spot 35 protein may be involved in normal physiological operation of the cerebellum through modulation of the NE or 5-HT system.

KW - Amino acids

KW - Cerebellum

KW - Norepinephrine

KW - Serotonin

KW - Spot 35 protein

KW - cGMP

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SN - 0014-2999

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

Involvement of spot 35 protein, a cerebellar protein, in modulation of Purkinje cell activity of the rat cerebellum

Abstract

Keywords

ASJC Scopus subject areas

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