Involvement of the brain type of ryanodine receptor in T-cell proliferation

Yasuhiro Hakamata, Seiichiro Nishimura, Junichi Nakai, Yasuyo Nakashima, Toru Kita, Keiji Imoto

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)


Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.

Original languageEnglish
Pages (from-to)206-210
Number of pages5
JournalFEBS Letters
Issue number2
Publication statusPublished - 1994 Sept 26


  • Calcium release
  • cDNA cloning
  • Cell proliferation
  • FK506
  • Jurkat T-lymphocyte
  • Ryanodine receptor


Dive into the research topics of 'Involvement of the brain type of ryanodine receptor in T-cell proliferation'. Together they form a unique fingerprint.

Cite this