Involvement of the brain type of ryanodine receptor in T-cell proliferation

Yasuhiro Hakamata; Seiichiro Nishimura; Junichi Nakai; Yasuyo Nakashima; Toru Kita; Keiji Imoto

doi:10.1016/0014-5793(94)00955-4

Involvement of the brain type of ryanodine receptor in T-cell proliferation

Yasuhiro Hakamata, Seiichiro Nishimura, Junichi Nakai, Yasuyo Nakashima, Toru Kita, Keiji Imoto

DEN - Dental Sciences

Kyoto University

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca²⁺ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.

Original language	English
Pages (from-to)	206-210
Number of pages	5
Journal	FEBS Letters
Volume	352
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(94)00955-4
Publication status	Published - 1994 Sept 26

Keywords

Calcium release
cDNA cloning
Cell proliferation
FK506
Jurkat T-lymphocyte
Ryanodine receptor

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10.1016/0014-5793(94)00955-4

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title = "Involvement of the brain type of ryanodine receptor in T-cell proliferation",

abstract = "Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.",

keywords = "Calcium release, cDNA cloning, Cell proliferation, FK506, Jurkat T-lymphocyte, Ryanodine receptor",

author = "Yasuhiro Hakamata and Seiichiro Nishimura and Junichi Nakai and Yasuyo Nakashima and Toru Kita and Keiji Imoto",

note = "Funding Information: AcknowledgmenWtse: t hankD r. T. lmagawafo r CHO cellst ransfected with the cardiacR YR cDNA, and M. Kuchiishi for technicala ssis-tance.T his investigationw ass upportedin part by researchg rantsf rom the Ministry of Education,S ciencea ndC ultureo f Japan and the lnsti-tute of Physicala nd ChemicalR esearch.",

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doi = "10.1016/0014-5793(94)00955-4",

language = "English",

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T1 - Involvement of the brain type of ryanodine receptor in T-cell proliferation

AU - Hakamata, Yasuhiro

AU - Nishimura, Seiichiro

AU - Nakai, Junichi

AU - Nakashima, Yasuyo

AU - Kita, Toru

AU - Imoto, Keiji

N1 - Funding Information: AcknowledgmenWtse: t hankD r. T. lmagawafo r CHO cellst ransfected with the cardiacR YR cDNA, and M. Kuchiishi for technicala ssis-tance.T his investigationw ass upportedin part by researchg rantsf rom the Ministry of Education,S ciencea ndC ultureo f Japan and the lnsti-tute of Physicala nd ChemicalR esearch.

PY - 1994/9/26

Y1 - 1994/9/26

N2 - Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.

AB - Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.

KW - Calcium release

KW - cDNA cloning

KW - Cell proliferation

KW - FK506

KW - Jurkat T-lymphocyte

KW - Ryanodine receptor

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Involvement of the brain type of ryanodine receptor in T-cell proliferation

Abstract

Keywords

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