IRF family of transcription factors as regulators of host defense

T. Taniguchi, K. Ogasawara, A. Takaoka, N. Tanaka

Research output: Contribution to journalReview articlepeer-review

1328 Citations (Scopus)


Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two structurally related members, IRF-1 and IRF-2, seven additional members have now been reported. In addition, virally encoded IRFs, which may interfere with cellular IRFs, have also been identified. Thus far, intensive functional analyses have been done on IRF-1, revealing a remarkable functional diversity of this transcription factor in the regulation of cellular response in host defense. Indeed, IRF-1 selectively modulates different sets of genes, depending on the cell type and/or the nature of cellular stimuli, in order to evoke appropriate responses in each. More recently, much attention has also been focused on other IRF family members. Their functional roles, through interactions with their own or other members of the family of transcription factors, are becoming clearer in the regulation of host defense, such as innate and adaptive immune responses and oncogenesis.

Original languageEnglish
Pages (from-to)623-655
Number of pages33
JournalAnnual Review of Immunology
Publication statusPublished - 2001


  • Cytokine
  • Interferon
  • Interferon regulatory factor
  • Oncogenesis
  • Transcriptional regulation


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