TY - JOUR
T1 - Iron-catalyzed chemoselective ortho arylation of aryl imines by directed C-H bond activation
AU - Yoshikai, Naohiko
AU - Matsumoto, Arimasa
AU - Norinder, Jakob
AU - Nakamura, Eiichi
PY - 2009/4/6
Y1 - 2009/4/6
N2 - No Fe-ar: Iron catalyzes an imine-directed C-H bond activation to introduce an ortho-aryl group to an acetophenone-derived imine using a diarylzinc reagent (see scheme), whereas palladium catalyzes the conventional substitution reaction . The title reaction features mild and selective C-H bond activation in the presence of aryl bromide, chloride, or sulfonate groups, and 1,2-dichloroisobutane is essential to achieve such selectivity.
AB - No Fe-ar: Iron catalyzes an imine-directed C-H bond activation to introduce an ortho-aryl group to an acetophenone-derived imine using a diarylzinc reagent (see scheme), whereas palladium catalyzes the conventional substitution reaction . The title reaction features mild and selective C-H bond activation in the presence of aryl bromide, chloride, or sulfonate groups, and 1,2-dichloroisobutane is essential to achieve such selectivity.
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U2 - 10.1002/anie.200900454
DO - 10.1002/anie.200900454
M3 - Article
AN - SCOPUS:70349783716
SN - 1433-7851
VL - 48
SP - 2925
EP - 2928
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 16
ER -