Irsogladine is a potent inhibitor of angiogenesis

Yasufumi Sato; Akio Morimoto; Akira Kiue; Kazuki Okamura; Ryoji Hamanaka; Kimitoshi Kohno; Michihiko Kuwano; Toshiie Sakata

doi:10.1016/0014-5793(93)81558-H

Irsogladine is a potent inhibitor of angiogenesis

Yasufumi Sato, Akio Morimoto, Akira Kiue, Kazuki Okamura, Ryoji Hamanaka, Kimitoshi Kohno, Michihiko Kuwano, Toshiie Sakata

New Industry Creation Hatchery Center (NICHe)

Oita University

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

We describe a novel inhibitor of angiogenesis, Irsogladine, an anti-ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.

Original language	English
Pages (from-to)	155-158
Number of pages	4
Journal	FEBS Letters
Volume	322
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(93)81558-H
Publication status	Published - 1993 May 10

Keywords

Angiogenesis
Irsogladine
Plasminogen activator

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0014-5793(93)81558-H

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title = "Irsogladine is a potent inhibitor of angiogenesis",

abstract = "We describe a novel inhibitor of angiogenesis, Irsogladine, an anti-ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.",

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T1 - Irsogladine is a potent inhibitor of angiogenesis

AU - Sato, Yasufumi

AU - Morimoto, Akio

AU - Kiue, Akira

AU - Okamura, Kazuki

AU - Hamanaka, Ryoji

AU - Kohno, Kimitoshi

AU - Kuwano, Michihiko

AU - Sakata, Toshiie

PY - 1993/5/10

Y1 - 1993/5/10

N2 - We describe a novel inhibitor of angiogenesis, Irsogladine, an anti-ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.

AB - We describe a novel inhibitor of angiogenesis, Irsogladine, an anti-ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.

KW - Angiogenesis

KW - Irsogladine

KW - Plasminogen activator

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JF - FEBS Letters

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Irsogladine is a potent inhibitor of angiogenesis

Abstract

Keywords

UN SDGs

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