Irsogladine is a potent inhibitor of angiogenesis

Yasufumi Sato, Akio Morimoto, Akira Kiue, Kazuki Okamura, Ryoji Hamanaka, Kimitoshi Kohno, Michihiko Kuwano, Toshiie Sakata

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


We describe a novel inhibitor of angiogenesis, Irsogladine, an anti-ulcer drug. Irsogladine inhibited plasminogen activator synthesis of, and tube formation by, human microvascular endothelial cells in type 1 collagen gel treated with an angiogenic growth factor, EGF. Furthermore, Irsogladine administered orally significantly inhibited in vivo angiogenesis in mice. Irsogladine may be useful in the treatment of diseases associated with angiogenesis.

Original languageEnglish
Pages (from-to)155-158
Number of pages4
JournalFEBS Letters
Issue number2
Publication statusPublished - 1993 May 10


  • Angiogenesis
  • Irsogladine
  • Plasminogen activator


Dive into the research topics of 'Irsogladine is a potent inhibitor of angiogenesis'. Together they form a unique fingerprint.

Cite this