TY - JOUR
T1 - Is Ca2+-activated potassium efflux involved in the formation of ischemic brain edema?
AU - Tominaga, Teiji
AU - Katagi, Hiroaki
AU - Ohnishi, S. Tsuyoshi
N1 - Funding Information:
The authors thank Dr. Christopher Miller, Bran-deis University, for his valuable suggestions for purifying charybdotoxin and Dr. Susan T. Smith of the University City Science Center for her editorial assistance. This work was supported by a grant from RHD, Inc., Tokyo, Japan.
PY - 1988/9/20
Y1 - 1988/9/20
N2 - A possible role of Ca2+-activated potassium efflux in brain ischemia was studied using a rat focal cortical infarction model. Three days after ischemic insult, tissue contents of water, sodium, potassium and calcium ions were measured. Charybdotoxin, a specific inhibitor of Ca2+-activated potassium efflux, was found to reduce the formation of ischemic brain edema when a dosage of 0.15 mg/kg was given by i.v. 20-30 min prior to the onset of ischemic insult.
AB - A possible role of Ca2+-activated potassium efflux in brain ischemia was studied using a rat focal cortical infarction model. Three days after ischemic insult, tissue contents of water, sodium, potassium and calcium ions were measured. Charybdotoxin, a specific inhibitor of Ca2+-activated potassium efflux, was found to reduce the formation of ischemic brain edema when a dosage of 0.15 mg/kg was given by i.v. 20-30 min prior to the onset of ischemic insult.
KW - Calcium-activated potassium channel
KW - Charybdotoxin
KW - Focal ischemia
KW - Ischemic brain edema
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U2 - 10.1016/0006-8993(88)90385-X
DO - 10.1016/0006-8993(88)90385-X
M3 - Article
C2 - 2465063
AN - SCOPUS:0023822437
SN - 0006-8993
VL - 460
SP - 376
EP - 378
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 2
ER -