Isolation, Structure Determination, and Synthesis of Neodysiherbaine A, a New Excitatory Amino Acid from a Marine Sponge

Ryuichi Sakai; Tatsuki Koike; Makoto Sasaki; Keiko Shimamoto; Chie Oiwa; Atsuko Yano; Katsuji Suzuki; Kazuo Tachibana; Hisao Kamiya

doi:10.1021/ol015798l

Isolation, Structure Determination, and Synthesis of Neodysiherbaine A, a New Excitatory Amino Acid from a Marine Sponge

Ryuichi Sakai, Tatsuki Koike, Makoto Sasaki, Keiko Shimamoto, Chie Oiwa, Atsuko Yano, Katsuji Suzuki, Kazuo Tachibana, Hisao Kamiya

LIF - Molecular and Chemical Life Science

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

matrix presented 2 : neodysiherbaine A A new excitatory amino acid, neodysiherbaine A (2), was isolated as a minor constituent of the aqueous extract from the marine sponge Dysidea herbacea. The structure was deduced by spectroscopic methods and established unambiguously by the total synthesis. The present synthesis, including as a key step cross-coupling of the 6/5-bicyclic core with an amino acid residue, is useful in constructing its structural analogues.

Original language	English
Pages (from-to)	1479-1482
Number of pages	4
Journal	Organic Letters
Volume	3
Issue number	10
DOIs	https://doi.org/10.1021/ol015798l
Publication status	Published - 2001 May 17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/ol015798l

Cite this

@article{803035a6d0d148c3b3456a1b2382f35f,

title = "Isolation, Structure Determination, and Synthesis of Neodysiherbaine A, a New Excitatory Amino Acid from a Marine Sponge",

abstract = "matrix presented 2 : neodysiherbaine A A new excitatory amino acid, neodysiherbaine A (2), was isolated as a minor constituent of the aqueous extract from the marine sponge Dysidea herbacea. The structure was deduced by spectroscopic methods and established unambiguously by the total synthesis. The present synthesis, including as a key step cross-coupling of the 6/5-bicyclic core with an amino acid residue, is useful in constructing its structural analogues.",

author = "Ryuichi Sakai and Tatsuki Koike and Makoto Sasaki and Keiko Shimamoto and Chie Oiwa and Atsuko Yano and Katsuji Suzuki and Kazuo Tachibana and Hisao Kamiya",

year = "2001",

month = may,

day = "17",

doi = "10.1021/ol015798l",

language = "English",

volume = "3",

pages = "1479--1482",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Isolation, Structure Determination, and Synthesis of Neodysiherbaine A, a New Excitatory Amino Acid from a Marine Sponge

AU - Sakai, Ryuichi

AU - Koike, Tatsuki

AU - Sasaki, Makoto

AU - Shimamoto, Keiko

AU - Oiwa, Chie

AU - Yano, Atsuko

AU - Suzuki, Katsuji

AU - Tachibana, Kazuo

AU - Kamiya, Hisao

PY - 2001/5/17

Y1 - 2001/5/17

N2 - matrix presented 2 : neodysiherbaine A A new excitatory amino acid, neodysiherbaine A (2), was isolated as a minor constituent of the aqueous extract from the marine sponge Dysidea herbacea. The structure was deduced by spectroscopic methods and established unambiguously by the total synthesis. The present synthesis, including as a key step cross-coupling of the 6/5-bicyclic core with an amino acid residue, is useful in constructing its structural analogues.

AB - matrix presented 2 : neodysiherbaine A A new excitatory amino acid, neodysiherbaine A (2), was isolated as a minor constituent of the aqueous extract from the marine sponge Dysidea herbacea. The structure was deduced by spectroscopic methods and established unambiguously by the total synthesis. The present synthesis, including as a key step cross-coupling of the 6/5-bicyclic core with an amino acid residue, is useful in constructing its structural analogues.

UR - http://www.scopus.com/inward/record.url?scp=0035902232&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035902232&partnerID=8YFLogxK

U2 - 10.1021/ol015798l

DO - 10.1021/ol015798l

M3 - Article

C2 - 11388846

AN - SCOPUS:0035902232

SN - 1523-7060

VL - 3

SP - 1479

EP - 1482

JO - Organic Letters

JF - Organic Letters

IS - 10

ER -

Isolation, Structure Determination, and Synthesis of Neodysiherbaine A, a New Excitatory Amino Acid from a Marine Sponge

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this