Isopimarane diterpene glycosides, isolated from endophytic fungus Paraconiothyrium sp. MY-42

Yoshihito Shiono; Miwako Kikuchi; Takuya Koseki; Tetsuya Murayama; Eunsang Kwon; Nobuhiro Aburai; Ken Ichi Kimura

doi:10.1016/j.phytochem.2011.04.016

Isopimarane diterpene glycosides, isolated from endophytic fungus Paraconiothyrium sp. MY-42

Yoshihito Shiono, Miwako Kikuchi, Takuya Koseki, Tetsuya Murayama, Eunsang Kwon, Nobuhiro Aburai, Ken Ichi Kimura

SCI - Research and Analytical Center for Giant Molecules

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Six isopimarane diterpenes, compounds 1-6, were isolated from the endophytic fungus Paraconiothyrium sp. MY-42. Compound 1 possesses a 19-glucopyranosyloxy group. Its structure was first elucidated by spectroscopic data analysis and finally confirmed by X-ray crystallography, whereas structures 2-6 were mainly elucidated based on the analysis of spectroscopic evidence. Compounds 2 and 3 showed moderate cytotoxicities against the human promyelocytic leukemia cell line HL60 (IC₅₀ 6.7 μM value for 2 and 9.8 μM for 3).

Original language	English
Pages (from-to)	1400-1405
Number of pages	6
Journal	Phytochemistry
Volume	72
Issue number	11-12
DOIs	https://doi.org/10.1016/j.phytochem.2011.04.016
Publication status	Published - 2011 Aug

Keywords

Cytotoxicity
Endophytic fungus
Isopimarane diterpenes
Paraconiothyrium sp.

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/j.phytochem.2011.04.016

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title = "Isopimarane diterpene glycosides, isolated from endophytic fungus Paraconiothyrium sp. MY-42",

abstract = "Six isopimarane diterpenes, compounds 1-6, were isolated from the endophytic fungus Paraconiothyrium sp. MY-42. Compound 1 possesses a 19-glucopyranosyloxy group. Its structure was first elucidated by spectroscopic data analysis and finally confirmed by X-ray crystallography, whereas structures 2-6 were mainly elucidated based on the analysis of spectroscopic evidence. Compounds 2 and 3 showed moderate cytotoxicities against the human promyelocytic leukemia cell line HL60 (IC50 6.7 μM value for 2 and 9.8 μM for 3).",

keywords = "Cytotoxicity, Endophytic fungus, Isopimarane diterpenes, Paraconiothyrium sp.",

author = "Yoshihito Shiono and Miwako Kikuchi and Takuya Koseki and Tetsuya Murayama and Eunsang Kwon and Nobuhiro Aburai and Kimura, {Ken Ichi}",

year = "2011",

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doi = "10.1016/j.phytochem.2011.04.016",

language = "English",

volume = "72",

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T1 - Isopimarane diterpene glycosides, isolated from endophytic fungus Paraconiothyrium sp. MY-42

AU - Shiono, Yoshihito

AU - Kikuchi, Miwako

AU - Koseki, Takuya

AU - Murayama, Tetsuya

AU - Kwon, Eunsang

AU - Aburai, Nobuhiro

AU - Kimura, Ken Ichi

PY - 2011/8

Y1 - 2011/8

N2 - Six isopimarane diterpenes, compounds 1-6, were isolated from the endophytic fungus Paraconiothyrium sp. MY-42. Compound 1 possesses a 19-glucopyranosyloxy group. Its structure was first elucidated by spectroscopic data analysis and finally confirmed by X-ray crystallography, whereas structures 2-6 were mainly elucidated based on the analysis of spectroscopic evidence. Compounds 2 and 3 showed moderate cytotoxicities against the human promyelocytic leukemia cell line HL60 (IC50 6.7 μM value for 2 and 9.8 μM for 3).

AB - Six isopimarane diterpenes, compounds 1-6, were isolated from the endophytic fungus Paraconiothyrium sp. MY-42. Compound 1 possesses a 19-glucopyranosyloxy group. Its structure was first elucidated by spectroscopic data analysis and finally confirmed by X-ray crystallography, whereas structures 2-6 were mainly elucidated based on the analysis of spectroscopic evidence. Compounds 2 and 3 showed moderate cytotoxicities against the human promyelocytic leukemia cell line HL60 (IC50 6.7 μM value for 2 and 9.8 μM for 3).

KW - Cytotoxicity

KW - Endophytic fungus

KW - Isopimarane diterpenes

KW - Paraconiothyrium sp.

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JF - Phytochemistry

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ER -

Isopimarane diterpene glycosides, isolated from endophytic fungus Paraconiothyrium sp. MY-42

Abstract

Keywords

ASJC Scopus subject areas

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