Isthmus organizer for mesencephalon and metencephalon

Harukazu Nakamura, Tatsuya Sato, Asuka Suzuki-Hirano

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)


The vertebrate central nervous system is elaborated from a simple neural tube. Brain vesicles formation is the first sign of regionalization. Classical transplantation using quail and chick embryos revealed that the mesencephalon-metencephalon boundary (isthmus) functions as an organizer of the mesencephalon and metencephalon. Fgf8 is accepted as a main organizing molecule of the isthmus. Strong Fgf8 signal activates the Ras-ERK signaling pathway to differentiate the cerebellum. In this review, the historical background of the means of identifying the isthmus organizer and the molecular mechanisms of signal transduction for tectum and cerebellum differentiation is reviewed.

Original languageEnglish
Pages (from-to)S113-S118
JournalDevelopment Growth and Differentiation
Issue numberSUPPL. 1
Publication statusPublished - 2008 Jun 1
Externally publishedYes


  • Cerebellum
  • Fgf8
  • Isthmus organizer
  • Ras-ERK pathway
  • Tectum

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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