Japan Arteriosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) - Rationale, design, and population characteristics

Akiko Harada, Hirotsugu Ueshima, Yasuo Ohashi, Hideaki Toyoshima, Yutaka Imai, Hideaki Nakagawa, Kazuaki Shimamoto, Akira Yamashina, Toshio Kushiro, Yutaka Kiyohara, Hiroyasu Iso

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Background: The Japan Arteriosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC) is a pooled study based on individual participant data from existing prospective cohort studies in Japan. Its purpose was to consider associations between risk factors and cardiovascular disease (CVD) outcomes, as well as differences between subgroups, defined by age, gender or geographical region, which could not be detected in the smaller samples. Methods and Results: Individual records for 66,691 participants in 21 cohort studies were pooled, accounting for a total of 575,628 person-years. From this data, there were 409 deaths attributed to stroke and 169 deaths attributed to coronary heart disease (CHD). Total stroke and CHD events were 1,478 and 178, respectively. Of the 1,424 total stroke events with a reported stroke subtype, 975 were classified as ischemic, 267 as hemorrhagic, and 178 as subarachnoid hemorrhage. Conclusion: The JALS-ECC collected data from existing cohort studies covering a diverse Japanese population, which has provided information about the effects of modifiable factors on the risks of the CVD. Such information should provide a reliable basis for establishing prevention strategies.

Original languageEnglish
Pages (from-to)1563-1568
Number of pages6
JournalCirculation Journal
Issue number10
Publication statusPublished - 2008


  • Cohort study
  • Coronary heart disease
  • Meta-analysis
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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