Keratoacanthoma Centrifugum Marginatum with Spontaneous Regression and Its Possible Differential Diagnosis

Ryo Amagai; Taku Fujimura; Yumi Kambayashi; Sadanori Furudate; Yota Sato; Kayo Tanita; Akira Hashimoto; Setsuya Aiba

doi:10.1159/000493089

Keratoacanthoma Centrifugum Marginatum with Spontaneous Regression and Its Possible Differential Diagnosis

Ryo Amagai, Taku Fujimura, Yumi Kambayashi, Sadanori Furudate, Yota Sato, Kayo Tanita, Akira Hashimoto, Setsuya Aiba

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Keratoacanthoma centrifugum marignatum (KCM) is a rare variant of keratoacanthoma, which is characterized by the dense infiltration of inflammatory cells throughout the dermis, especially around the keratinocytic islands. Therefore, it is sometimes difficult to differentiate between KCM and cutaneous T-cell lymphomas. In this report, we describe a case of KCM with spontaneous regression that showed dense infiltration of CD3+CD8+ T cells. Our present case suggested the importance of investigating tumor-infiltrating lymphocytes to avoid the misdiagnosis of KCM as cutaneous T-cell lymphoma.

Original language	English
Pages (from-to)	671-675
Number of pages	5
Journal	Case Reports in Oncology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1159/000493089
Publication status	Published - 2018 Sept 1

Keywords

Cutaneous T-cell lymphoma
Keratoacanthoma centrifugum marginatum
Spontaneous regression
Tumor-infiltrating lymphocytes

ASJC Scopus subject areas

Oncology

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10.1159/000493089

Cite this

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title = "Keratoacanthoma Centrifugum Marginatum with Spontaneous Regression and Its Possible Differential Diagnosis",

abstract = "Keratoacanthoma centrifugum marignatum (KCM) is a rare variant of keratoacanthoma, which is characterized by the dense infiltration of inflammatory cells throughout the dermis, especially around the keratinocytic islands. Therefore, it is sometimes difficult to differentiate between KCM and cutaneous T-cell lymphomas. In this report, we describe a case of KCM with spontaneous regression that showed dense infiltration of CD3+CD8+ T cells. Our present case suggested the importance of investigating tumor-infiltrating lymphocytes to avoid the misdiagnosis of KCM as cutaneous T-cell lymphoma.",

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T1 - Keratoacanthoma Centrifugum Marginatum with Spontaneous Regression and Its Possible Differential Diagnosis

AU - Amagai, Ryo

AU - Fujimura, Taku

AU - Kambayashi, Yumi

AU - Furudate, Sadanori

AU - Sato, Yota

AU - Tanita, Kayo

AU - Hashimoto, Akira

AU - Aiba, Setsuya

PY - 2018/9/1

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N2 - Keratoacanthoma centrifugum marignatum (KCM) is a rare variant of keratoacanthoma, which is characterized by the dense infiltration of inflammatory cells throughout the dermis, especially around the keratinocytic islands. Therefore, it is sometimes difficult to differentiate between KCM and cutaneous T-cell lymphomas. In this report, we describe a case of KCM with spontaneous regression that showed dense infiltration of CD3+CD8+ T cells. Our present case suggested the importance of investigating tumor-infiltrating lymphocytes to avoid the misdiagnosis of KCM as cutaneous T-cell lymphoma.

AB - Keratoacanthoma centrifugum marignatum (KCM) is a rare variant of keratoacanthoma, which is characterized by the dense infiltration of inflammatory cells throughout the dermis, especially around the keratinocytic islands. Therefore, it is sometimes difficult to differentiate between KCM and cutaneous T-cell lymphomas. In this report, we describe a case of KCM with spontaneous regression that showed dense infiltration of CD3+CD8+ T cells. Our present case suggested the importance of investigating tumor-infiltrating lymphocytes to avoid the misdiagnosis of KCM as cutaneous T-cell lymphoma.

KW - Cutaneous T-cell lymphoma

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KW - Spontaneous regression

KW - Tumor-infiltrating lymphocytes

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Keratoacanthoma Centrifugum Marginatum with Spontaneous Regression and Its Possible Differential Diagnosis

Abstract

Keywords

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