Kinetic control of threading of cyclodextrins onto axle molecules

Tomoya Oshikiri, Yoshinori Takashima, Hiroyasu Yamaguchi, Akira Harada

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)


We report here, for the first time, kinetic control of the face-direction of cyclodextrin (CD) in the construction of a pseudo-rotaxane with an alkyl chain bearing pyridyl end caps. The yields of complexes of CDs with guest alkyl derivatives were controlled by the simple change of the position and the number of methyl groups bound to the pyridyl moiety. Single-substituted pyridyl groups attached to the ends of the alkyl chain regulated the rate for CDs passing them. Two methyl substituents could clearly govern the degree of complex formation of CD with guest molecules and resulted in the distinction of face-direction of CD molecules entering the gates at guest ends.

Original languageEnglish
Pages (from-to)12186-12187
Number of pages2
JournalJournal of the American Chemical Society
Issue number35
Publication statusPublished - 2005 Sept 7
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


Dive into the research topics of 'Kinetic control of threading of cyclodextrins onto axle molecules'. Together they form a unique fingerprint.

Cite this