Kinetic Switching of the Concentration/Separation Behavior of Microdroplets

Mao Fukuyama, Akihide Hibara, Yumi Yoshida, Kohji Maeda

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


This work demonstrates that the solute concentration inside 100 micrometer-sized aqueous microdroplets can be controlled by adjusting the time required for the aqueous nanometer-sized droplets (nanodroplet) or reverse micelles to pass over the surface of the microdroplet. The kinetics of molecular transport between the microdroplets and the nanodroplets was investigated by utilizing a microdroplet array, and on the basis of these results, a control over the concentration selectivity of the contents of the microdroplet was achieved. This method is operationally simple and can be potentially applied as a pretreatment method for microanalytical systems that require high-density microdroplet arrays. This method can also be utilized for parallel small sample analyses such as single cell analysis.

Original languageEnglish
Pages (from-to)9279-9283
Number of pages5
JournalAnalytical Chemistry
Issue number17
Publication statusPublished - 2017 Sept 5


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